Teprotumumab in Thyroid-Associated Ophthalmopathy: Rationale for Therapeutic Insulin-Like Growth Factor–I Receptor Inhibition

Abstract: Thyroid-associated ophthalmopathy (TAO) is an autoimmune component of Graves' disease for which no currently available medical therapy provides reliable and safe benefit. Based on insights generated experimentally over the past several decades, the insulin-like growth factor–I receptor (IGF-IR) has been implicated in the pathogenesis of TAO. Furthermore, an IGF-IR inhibitor, teprotumumab, has emerged from 2 clinical trials as a promising treatment for active, moderate to severe TAO. This brief review intends to provide an overview of the rationale underlying the development of teprotumumab for this disease. It is possible that teprotumumab will soon take its place in our therapeutic armamentarium for active TAO.
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Basic and Translational Research Source Type: research

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Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
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Source: Anesthesiology - Category: Anesthesiology Source Type: research
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Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Among the group of thymic epithelial tumors (TET), thymomas often show either uncertain or explicit malignant biological behavior, local invasiveness, and intrathoracic relapse and are often difficult to manage. From the initial stages, thymic carcinomas tend to show aggressive behavior and extrathoracic spread. Moreover, the interplay of epithelial cells and thymocytes in thymomas causes complex immune derangement and related systemic autoimmune diseases. Due to their rare occurrence and to the limited funding opportunities available for rare tumors, it is challenging to make advances in clinical and translational researc...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Background: Thyroid-associated ophthalmopathy (TAO), an autoimmune process affecting the tissues surrounding the eye, most commonly develops in individuals with Graves ’ disease. It is disfiguring, can cause vision loss, and dramatically lessens the quality of life in patients. There has been an absence of approved medical therapies for TAO with proven effectiveness and safety in multicenter, placebo-controlled, and adequately powered clinical trials.Summary: The following is a brief overview of the rationale for developing a monoclonal antibody inhibitor of the insulin-like growth factor-I receptor into a treatment ...
Source: European Thyroid Journal - Category: Endocrinology Source Type: research
America ’s biopharmaceutical companies are at the heart of a robust research and development (R&D) ecosystem that develops more innovative medicines than any other country in the world. In recent years, rapid advances in scientific discovery have ushered in a new era of medicine, transforming our ability to treat, and in some cases cure, some of the most challenging diseases, including cancer, rare diseases and autoimmune conditions. These advancements are due to the productivity of the United States ’ biomedical research ecosystem, which is sustained by a policy framework that is designed to support and advanc...
Source: The Catalyst - Category: Pharmaceuticals Authors: Tags: Research and Development Intellectual Property & D Focus Coronavirus Source Type: news
Authors: Bondy SC, Campbell A Abstract Melatonin is well known as a neuroendocrine hormone that promotes sleep. However, the many other attributes of melatonin are less apparent and not as widely appreciated. The purpose of this review is to summarize the qualities of melatonin relating to immune function. The relevance of melatonin in partially or wholly restoring optimal function in a series of disorders related to immune dysfunction is addressed. This includes the potential relief of both autoimmune diseases and many other ailments involving abnormal immune responses, including the overall diminished effectivene...
Source: Current Aging Science - Category: Geriatrics Tags: Curr Aging Sci Source Type: research
We describe a 16-year-old female who presented to our clinic with 1-month complaints of diplopia and strabismus, visual acuity deterioration, and ocular irritation. Her examination showed crossed diplopia and alternating exotropia of 25 prism diopters, severe blepharitis, conjunctival hyperemia, corneal pannus, epithelial irregularities, and subepithelial opacities. Workup included pediatric neurologic examination, laboratory tests, imaging, and electrophysiological tests. Diagnoses of OMG and blepharitis with ocular surface disease were made. Topical treatment included eyelid hygiene, tea tree oil scrubbing, topical stero...
Source: Case Reports in Ophthalmology - Category: Opthalmology Source Type: research
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Source: Pediatric Rheumatology - Category: Rheumatology Authors: Tags: Case Report Source Type: research
Publication date: Available online 12 July 2020Source: Autoimmunity ReviewsAuthor(s): Paola Migliorini, Paola Italiani, Federico Pratesi, Ilaria Puxeddu, Diana Boraschi
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
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