The Association of Methylprednisolone Dosing to Cessation of Myotonia in a Patient with Myotonic Dystrophy Type 1

We report the case of a patient suffering from duplicity of DM1 and ulcerative colitis (UC) whose treatment for UC included, among other drugs, repeated administrations of descending doses of methylprednisolone and in whom we found an association between initiation of methylprednisolone dosage and cessation of myotonia.
Source: Neuromuscular Disorders - Category: Neurology Authors: Tags: Case Report Source Type: research

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Conclusions: Anorectal function is impaired in IBD patients with perianal disease. Fecal incontinence correlates with poorer quality of life. Anorectal manometry and ultrasonography are useful tools for evaluating IBD patients. PMID: 31625422 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with FMT,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study showed a good safety and tolerability profile of the studied substance (Monteleone et al., 2012). Since TGFβ has been described to induce the profibrogenetic response of fibroblasts, patients were monitored for 6 months with intestinal ultrasonography, not showing signs of intestinal stenosis. Moreover, half of the patients maintained remission during the 6 months follow up period (Zorzi et al., 2012). Afterwards, a randomized, double-blind, phase 2 study was conducted in CD patients with inflammatory lesions in the terminal ileum and/or right colon, with steroid-dependence/resistance, randomized to three ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study was carried out in accordance with the recommendations of “NIH Guide for Care and Use of Laboratory Animal protocols” and of the Institutional Animal Care and Use Committee of Shiga University of Medical Science (SUMS). The protocol was approved by SUMS. Six adult male Balb/c mice (5-weeks-old) were purchased from Clea Japan Inc. (Konan, Japan). Each mouse (labeled H1-H6) received subcutaneous injections of 0.1 ml of TiterMax Gold adjuvant (Sigma-Aldrich, Saint-Louis, MO, USA) containing 5 mg/ml KLH-conjugated peptide into multiple sites of the neck and back skin with at a 2-week interval. Antisera, ...
Source: Frontiers in Neuroanatomy - Category: Neurology Source Type: research
During the 20th century, medicine became very good at compartmentalizing different systems of the body in order to understand them better. However, today we are increasingly realizing that different systems of the body are interconnected and cannot be completely understood in isolation. The brain-gut connection is one very important example of this phenomenon. Anatomy of the brain-gut connection What exactly is the connection between brain and gut? The brain sends signals to the digestive, or gastrointestinal (GI), tract via the sympathetic (“fight or flight”) nervous system and the parasympathetic (“rest...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Complementary and alternative medicine Digestive Disorders Health Mind body medicine Pain Management Source Type: blogs
Abstract Neuroblastoma (NB) is a tumor arising from the sympathetic nervous system during infancy and early childhood. High-risk patients who relapse often fail to respond to further therapy, which results in 5-year survival rate for this patient group below 5%. Therefore, there continues to be an urgent need for innovative treatments. Recently, we found that sulfasalazine (SSZ), an FDA-approved drug for the treatment of rheumatoid arthritis and ulcerative colitis induces anti-proliferative effects in NB tumor cells. SSZ was recently shown to inhibit sepiapterin reductase (SPR), a key enzyme that produces tetrahyd...
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research
Nearly all diseases have a genomic basis. This varies from rare ‘single-gene disorders’ such as Duchenne muscular dystrophy, to ‘complex’ or ‘polygenic’ diseases such as type II diabetes mellitus and ulcerative colitis. Cancer is a genomic disease in which tumour evolution is driven by serial acquisition of somatic mutations. Investigation of genetic disorders has been predicated on available technologies, which until recently have been expensive, slow, low-throughput and therefore limited in availability.
Source: Medicine - Category: Internal Medicine Authors: Tags: Medicine and other specialties Source Type: research
Authors: Xu Z, Wei B, Qiu Y, Zhang T Abstract Purpose: Patients with ulcerative colitis (UC) frequently present with psychological disturbances as well as dysfunctions of autonomic nervous system (ANS). Salivary alpha-amylase (sAA) secretion is predominantly controlled by sympathetic nervous activity, while salivary fluid secretion is by parasympathetic nervous activity. Thus, it is speculated that alterations of salivary secretion may be addressed in UC populations. Methods: Thirty-five UC patients as well as 32 age- and sex-matched healthy controls were enrolled. Saliva samples before and after citric acid st...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
An excerpt from At Peace: Choosing a Good Death After a Long Life. Copyright © 2018 by Samuel Harrington, MD. Reprinted with permission of Grand Central Publishing. All rights reserved. The momentum to treat in America is unmatched around the globe or throughout history. As a result, we spend twice as much on medical care as the next most expensive country. A very large percentage of that money is spent in the last six months of life. What fuels the momentum to treat? American exceptionalism, for one. This is an ingrained feeling that the United States and its citizens are not only different but are the best...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Geriatrics Hospital-Based Medicine Primary Care Source Type: blogs
Abstract Sympathetic system modulation by stellate ganglion blockade may modulate immune dysfunction and significantly improve symptoms of chronic ulcerative colitis. PMID: 28533676 [PubMed - indexed for MEDLINE]
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
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