Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch

Hypoxia is a potent molecular signal for cellular metabolism, mitochondrial function, and migration. Conditions of low oxygen tension trigger regulatory cascades mediated via the highly conserved HIF-1 α post-tra...

Source: BMC Immunology - March 18, 2020 Category: Allergy & Immunology Authors: Shannon P Hilchey, Mukta G Palshikar, Jason A Emo, Dongmei Li, Jessica Garigen, Jiong Wang, Eric S Mendelson, Valentina Cipolla, Juilee Thakar and Martin S Zand Tags: Research Article Source Type: research