Sources and lesion-induced changes of VEGF expression in brainstem motoneurons

In conclusion, the low VEGF expression observed in glial cells suggests that these cells are not the main source of VEGF for brainstem motoneurons. Therefore, the higher VEGF expression observed in motoneurons innervating extraocular muscles is likely due either to the fact that this factor is more avidly taken up from the target muscles, in basal conditions, or is produced by these motoneurons themselves, and acts in an autocrine manner after axotomy.

Source: Anatomy and Embryology - March 17, 2020 Category: Anatomy Source Type: research