Gut microbiota in neonates with congenital gastrointestinal surgical conditions: a prospective study.

CONCLUSIONS: During hospitalization, neonates with CGISCs develop gut dysbiosis and deficiency of SCFAs.
IMPACT: During hospitalisation, neonates with congenital gastrointestinal surgical conditions develop gut dysbiosis with deficiency of Bifidobacteria and Bacteroides and increased abundance of Escherichia-Shigella and Pseudomonas. They also have low levels of short chain fatty acids in their stools compared to healthy infants.This is the first study evaluating the gut microbiota using 16S ribosomal RNA sequencing methods and stool short chain fatty acids in neonates with congenital gastrointestinal surgical conditions and comparing them to healthy infants.The findings of this study will pave the way for randomised trials of bifidobacterial supplementation in neonates with congenital gastrointestinal surgical conditions.
PMID: 32179871 [PubMed - as supplied by publisher]

Source: Pediatric Research - March 15, 2020 Category: Pediatrics Authors: Rao SC, Esvaran M, Patole SK, Simmer KN, Gollow I, Keil A, Wemheuer B, Chen L, Conway PL Tags: Pediatr Res Source Type: research