Albert Camus' The plague
First of three epidemic/pandemic related posts, but going beyond the medical and health science.As it happens, I was reading this book when the current coronavirus outbreak started. There is aninteresting piece about the book, written at the end of last week, on Literary Hub.The novel describes a fictional outbreak of bubonic plague in the town of Oran in Algeria, people's reactions to it, and each other, and the decisions that had to be taken.I am not (and neither is the author of the piece) comparing COVID-19 to bubonic plague but reading the story now does make some of those issues take on a certain relevance.
As of April 21, 2020, more than 2.5 million cases of coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, have been reported in 210 countries and territories, with the death toll at 171,810. Both chloroquine and hydroxychloroquine have gained considerable media attention as possible therapies, resulting in a significant surge in demand. In overdose, both medications can cause severe, potentially life-threatening effects. Here, we present a brief overview of the pharmacology of chloroquine and hydroxychloroquine, manifestations of toxicity, and treatment considerations.
The coronavirus disease 2019 (COVID-19), seems to have a cardiovascular tropism characterized by high incidence of myocardial infarction especially for patients with severe infections recovered in intensive care units. In their letter, the Authors state that oxidative stress could play a pivotal role to determine cardiovascular complications in COVID-19. We agree about this issue. In particular, NADPH oxidase-2 (NOX-2), that it is considered one of the most important sources of superoxide anion in human , plays a role in systemic inflammation and pathogenesis of several RNA virus as the influenza virus .
Additionally, side effects were more common among participants in the HCQ group than the placebo group. One expert says the results raise the question of whether some ongoing trials should stop.Medscape Medical News
Authors: Kerboua KE Abstract COVID-19 exhibits a non-yet elucidated heterogeneity dominated by mild form of the illness. Nevertheless, mortality is frequent among patients with a delayed innate immune response that suddenly exacerbates during the second week after admission leading to a lethal over inflammation. Therefore, this rapid and unpredictable deterioration requires timely prediction of COVID-19 refractoriness and critical illness. The two biomarkers readily available in routine laboratories, blood lymphocytes and neutrophil counts, are expected to provide an accurate clinical tool to incline reasonable med...
Publication date: Available online 2 June 2020Source: Biosensors and BioelectronicsAuthor(s): Feiyun Cui, H. Susan Zhou
Authors: Arrese M PMID: 32482463 [PubMed - as supplied by publisher]
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Michael P. McRae, Glennon W. Simmons, Nicolaos J. Christodoulides, Zhibing Lu, Stella K. Kang, David Fenyo, Timothy Alcorn, Isaac P. Dapkins, Iman Sharif, Deniz Vurmaz, Sayli S. Modak, Kritika Srinivasan, Shruti Warhadpande, Ravi Shrivastav, John T. McDevitt The COVID-19 Severity Score combines multiplex biomarker measurements and risk factors in a statistical learning algorithm to predict mortality. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Discussion volume is unique in the hundred plus year history of the Faraday Discussion series. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
One of America’s most immediate needs is to assess the spread of COVID-19 by quickly and widely testing for infection. That’s where Aperiomics comes in to play. This small business in Ashburn, VA, with early-stage research and development funding from the National Science Foundation’s Small ...This is an NSF Multimedia Gallery item.
An infectious outbreak can conclude in more ways than one, historians say. But for whom does it end, and who gets to decide?