Quality of life in heart failure with preserved ejection fraction: importance of obesity, functional capacity, and physical inactivity

ConclusionsQuality of life in HFpEF is poorest in patients who are young, obese and have diabetes, and is more robustly tied to measures reflecting functional capacity and daily activity levels rather than elevations in NT ‐proBNP or prior HF hospitalization. These findings have major implications for the understanding of QOL in HFpEF and for the design of future clinical trials targeting symptom improvement in HFpEF.Clinical Trial Registration: RELAX, NCT00763867; NEAT ‐HFpEF, NCT02053493; INDIE‐HFpEF, NCT02742129.

Source: European Journal of Heart Failure - March 18, 2020 Category: Cardiology Authors: Yogesh N.V. Reddy, Aruna Rikhi, Masaru Obokata, Sanjiv J. Shah, Gregory D. Lewis, Omar F. AbouEzzedine, Shannon Dunlay, Steven McNulty, Hrishikesh Chakraborty, Lynne W. Stevenson, Margaret M. Redfield, Barry A. Borlaug Tags: Research Article Source Type: research