The clinical, radiological, and immunohistochemical characteristics and outcomes of primary intracranial gliosarcoma: a retrospective single-centre study

This study aimed to identify risk factors for progression-free survival (PFS) and overall survival (OS) in these cases. This retrospective single-centre study evaluated 103 patients (median age, 51  years; 67 men [65%]) with primary intracranial gliosarcoma between 2006 and 2017. Treatments included surgery (GTR, 63 patients; STR, 39 patients; biopsy, 1 patient), radiotherapy (adjuvant, 76 patients; exclusive treatment, 1 patient), and chemotherapy (adjuvant temozolomide, 52 patients; adjuvan t nimustine/teniposide, 19 patients; adjuvant bevacizumab, 1 patient; exclusive nimustine/teniposide treatment, 1 patient). The median OS was 13.3 months, and the median PFS was 9.1 months. In the multivariate analyses, the poor prognostic factors were ependymal lining enhancement of the lateral v entricle (PFS, HR 2.406,p = 0.005; OS, HR 2.946,p = 0.009) and enhancement in the motor functional cortex (PFS, HR 2.892,p = 0.002; OS, HR 2.639,p = 0.009). Good OS was predicted by adjuvant radiotherapy alone (HR 0.071,p <  0.001), adjuvant temozolomide-based chemotherapy alone (HR 0.063,p = 0.005), adjuvant temozolomide-based chemotherapy with concurrent radiotherapy (HR 0.056,p <  0.001), and salvage surgery at recurrence (HR 0.449,p = 0.031). The present study revealed that, in patients with primary intracranial gliosarcoma, enhancement in the functional motor cortex and ependymal lining enhancement of the lateral ventricle were both poor prognostic ...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research