Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90.

We report here on a series of benzo[d]thiazole and 4,5,6,7-tetrahydrobenzo[d]thiazole derivatives with robust and selective activities against influenza A (H1N1, H3N2) and influenza B viruses. Two compounds, 1 and 4, have low micromolar EC50 values and show high binding affinities for Hsp90, which suggests that inhibition of Hsp90 is the mechanism underlying their antiviral effects. These compounds represent suitable scaffolds for designing novel Hsp90 inhibitors with favourable activities against influenza virus.
PMID: 32171985 [PubMed - as supplied by publisher]

Source: Bioorganic Chemistry - March 7, 2020 Category: Chemistry Authors: Lamut A, Gjorgjieva M, Naesens L, Liekens S, Lillsunde KE, Tammela P, Kikelj D, Tomašič T Tags: Bioorg Chem Source Type: research