Docking, Synthesis and Evaluation of the Antifungal Activity of Pyrimido[4,5-b]Quinolins

Conclusion:5-(3,4-dihydroxyphenyl)-8,8-dimethyl-2-(methylthio)-5,8,9,10 tetrahydropyrimido[4,5-b]quinoline-4,6(3H,7H)-dione (D13) exhibited inhibitory and fungicidal activities against the tested yeasts. The specific binding mode or the binding orientation of more efficient compounds to CYP51 active site, have been also performed by molecular modeling investigations and showed that there is a good correlation with biological test.
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research