Tumor ‐Associated Macrophages (TAM) are recruited to the aging prostate epithelial lesions and become intermingled with basal cells

ConclusionIn conclusion, macrophages were recruited into the prostate epithelium and presented diverse phenotypes and morphology, consistent with changes reflected in the hormonal environment. Macrophages with the TAM phenotype were found restricted to areas of premalignant and malignant lesions in aging prostates, denoting a possible involvement in cancer progression. In contrast, M2 macrophages were found in the regressed epithelium after castration.

Source: Andrology - March 17, 2020 Category: Urology & Nephrology Authors: Hip ácia Werneck‐Gomes, Gabriel H. Campolina‐Silva, Bruna T. Maria, Maria C. Barata, Germán A.B. Mahecha, Rex A. Hess, Cleida A. Oliveira Tags: ORIGINAL ARTICLE Source Type: research