Vaccinations and Screening Examinations – Prevention Awareness Among Children of Childhood Cancer Survivors in Germany

Discussion and conclusion CCS’ offspring showed comparable to significantly higher participation levels of recommended vaccinations and screening examinations than their peers from the German general population. In contrast to the general population the attendance of CCS’ offspring did not decrease with rising age. CCS’ own experiences and increased worry about their children’s health may lead to a higher prevention awareness. This should be considered in counselling parents with a cancer history. Hintergrund Impfraten und Teilnahme an Vorsorgeuntersuchungen sind ein Indikator für das Bewusstsein für Gesundheitsprävention. Wir untersuchten die Teilnahme von Kindern ehemaliger Krebspatienten in einer deutschlandweiten Studie. Patienten und Methoden Ehemalige kinderonkologische Patienten wurden zur Inanspruchnahme von Impfungen und Vorsorgeuntersuchungen ihrer leiblichen Kinder befragt. Daten aus der deutschen Allgemeinbevölkerung standen für einen Vergleich per Matched-pair Analyse zur Verfügung (KiGGS-Basiserhebung, Robert Koch-Instituts, n=17,641). Ergebnisse Insgesamt beantworteten 852/1,299 (65,6%) ehemalige Patienten 1,340 Fragebögen zur Gesundheit ihrer Kinder. Die Impfquoten für Tetanus, Diphtherie und Keuchhusten entsprachen denen der deutschen Allgemeinbevölkerung (Tetanus 99,1 vs. 98,4%). Impfungen gegen Mumps, Masern und Röteln wurden signifikant häufiger bei Kindern ehemaliger Patienten ...
Source: Klinische Padiatrie - Category: Pediatrics Authors: Tags: Original Article Source Type: research

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Authors: Noda A, Sakai T, Obara T, Miyazaki M, Tsuchiya M, Oyanagi G, Murai Y, Mano N Abstract BACKGROUND: There are no reports on investigations of the characteristics of adverse drug reaction (ADR) reports for pediatric patients in the Japanese Adverse Drug Event Report database (JADER) and the utility of database for drug safety surveillance in these patients. METHOD: We aimed to evaluate ADR reports for pediatric patients in the JADER. We used spontaneous ADR reports included in the JADER since April 1, 2004, to December 31, 2017, which was downloaded in April 2018. In a total of 504,407 ADR reports, the nu...
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
ConclusionsUnlike [18F]FDG, [18F]BODIPY 1 showed prominent accumulation in BAT under both inactive and stimulated status. [18F]BODIPY 1 may serve as a valuable BAT PET agent to possibly assess BAT mitochondria density, thus BAT thermogenic capacity after further evaluation.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsHypoxia modulation may play a role in nal-IRI ’s mechanism of action. Nal-IRI demonstrated greater anti-tumor activity in the more aggressive and hypoxic tumor model. Furthermore, hypoxia imaging provided early prediction of treatment response.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
AbstractPurposeTo investigate and validate the potential role of a radiomics signature in predicting the side-specific probability of extracapsular extension (ECE) of prostate cancer (PCa).ProceduresThe preoperative magnetic resonance imaging data of 238 prostatic samples from 119 enrolled PCa patients were retrospectively assessed. The samples with were randomized in a two-to-one ratio into training (n = 74) and validation (n = 45) datasets. The radiomics features were derived from T2-weighted images (T2WIs). The optimal radiomics features were identified from the least absolute shrinkage and s...
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsIntegrated [68Ga]PSMA-11 PET/MRI provides a similarly high diagnostic performance for localization of recurrent PC as PET/CT. For the detection of local recurrences [68Ga]PSMA-11 PET/MRI is superior compared with [68Ga]PSMA-11 PET/CT.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 25 May 2020Source: Life SciencesAuthor(s): Serena L'Abbate, Ilaria Russo, Claudia Kusmic
Source: Life Sciences - Category: Biology Source Type: research
In the May 2020 issue of BioScience, AIBS President Dr. Charles Fenster and Executive Director Dr. Robert Gropp urge governments to coordinate to promote greater understanding of the SARS-CoV-2 pandemic, including the development of a vaccine. They further call on governments to “build the infrastructure needed to foster timely scientific exchange and the conversion of scientific information into responsible public policy - both domestically and internationally, for the current and future crises.” They further warn, “Understanding the origins of the current global health crisis resulting from the novel c...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
Vaccination is a mainstay in preventive medicine, reducing morbidity and mortality from infection, largely by generating pathogen-specific neutralizing antibodies. However, standard immunization strategies are insufficient with increasing age due to immunological impediments, including defects in T follicular helper (Tfh) cells. Here, we found that Tfh generation is inversely linked to the expression of the ecto-NTPDase CD39 that modifies purinergic signaling. The lineage-determining transcription factor BCL6 inhibited CD39 expression, while increased Tfh frequencies were found in individuals with a germline polymorphism p...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
CONCLUSION: The prevalence of psychiatric disorders among NKD was quite higher than in the general population of South Korea. PMID: 32450622 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Longest official mourning period in Spain ’s democracy; unrest grows in UK PM’s party over Dominic Cummings lockdown breach; WHO says Americas are new Covid-19 epicentre. Follow the latest updatesGlobal report: Germany to relax travel curbs as Spain mourns Covid-19 victimsTory unrest increases pressure on PM to sack Dominic CummingsAustralia coronavirus – liveCoronavirus latest: at a glance5.21amBSTIndonesia said Tuesday it is deploying 340,000 troops to clamp down on rampant social-distancing violations as coronavirus infections surge in the world ’s fourth most populous country, AFP reports.The mi...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Australia news UK news US news Infectious diseases Science Africa Middle East and North Africa Americas Asia Pacific Russia China Brazil Microbiology Medical research Europe Spain Source Type: news
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