Preparation, optimization and characterization of chitosan-coated for solubility enhancement of ...

In this study effective parameters to preparation of nanoliposomes coated by chitosan (CCLs) were screened optimized by experimental design. Particle size, polydispersity index and surface potential of optimized CCLs have 155.8±3.5 nm, 0.229±0.022 and 25.2±3.5 mV, respectively. FMD was loaded in optimized CCLs 98.94±0.7%. Size of CCLs have verified by atomic force electron microscope. CCLs loaded by FMD were dried and in vitro study was performed to test release of FMD from powder. Results showed that solubility and dissolution of FMD increased by loading in CCLs in comparison to crystalline FMD and physical mixture of FMD and materials of CCLs.
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research