Relative Ratio and Level of Amyloid-β 42 Surrogate in Cerebrospinal Fluid of Familial Alzheimer Disease Patients with Presenilin 1 Mutations.

Conclusion: A higher relative ratio of the CSF Aβ42 surrogate in PS1-FAD patients is not due to its increase in CSF, suggesting that massive Aβ42 accumulation in the PS1-FAD brain occurs without an apparent increase in Aβ42 secretion. © 2013 S. Karger AG, Basel.
PMID: 24192669 [PubMed - as supplied by publisher]

Source: Neuro-Degenerative Diseases - October 30, 2013 Category: Neurology Authors: Tagami S, Okochi M, Yanagida K, Kodama T, Arai T, Kuwano R, Ikeuchi T, Takeda M Tags: Neurodegener Dis Source Type: research