IJERPH, Vol. 17, Pages 1938: Lower Serum Fibroblast Growth Factor 21 Levels are Associated with Normal Lumbar Spine Bone Mineral Density in Hemodialysis Patients

IJERPH, Vol. 17, Pages 1938: Lower Serum Fibroblast Growth Factor 21 Levels are Associated with Normal Lumbar Spine Bone Mineral Density in Hemodialysis Patients International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061938 Authors: Yin-Ting Wu Bang-Gee Hsu Chih-Hsien Wang Yu-Li Lin Yu-Hsien Lai Chiu-Huang Kuo Recent evidence has indicated that fibroblast growth factor 21 (FGF21) regulates longitudinal bone growth, with increased FGF21 levels leading to bone loss. The present study evaluated the relationship between bone mineral density (BMD) and serum FGF21 levels in patients undergoing hemodialysis (HD). We analyzed blood samples from 95 patients undergoing HD and measured BMD using dual-energy X-ray absorptiometry of the lumbar vertebrae (L2–L4). Serum FGF21 concentrations were determined using a commercially available enzyme-linked immunosorbent assay kit. Thirteen (11.6%) patients were found to have osteoporosis, 27 (28.4%) osteopenia, and 57 patients had normal BMD. Advanced age and decreased body mass index, height, body weight, waist circumference, and triglyceride level were associated with lower lumbar T-scores, as were increased alkaline phosphatase, urea reduction rate, fractional clearance index for urea, and FGF21 levels. Low log-FGF21, increased body mass index, increased pre-HD body weight, and increased logarithmically transformed triglycerides (log-TG) were found to be significantly and independentl...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research

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Publication date: Available online 24 May 2020Source: PhytomedicineAuthor(s): Nani Wang, Pingcui Xu, Xuping Wang, Weixuan Yao, Binjie Wang, Yuanzhao Wu, Dan Shou
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Conditions:   Osteoporosis;   Degenerative Lumbar Diseases Intervention:   Sponsor:   Peking University Third Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Vitamin D Status;   Osteoporosis;   Sarcopenia Intervention:   Sponsors:   University of Ulster;   Western Health and Social Care Trust Suspended
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Osteoporosis;   Degenerative Lumbar Diseases Intervention:   Sponsor:   Peking University Third Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Vitamin D Status;   Osteoporosis;   Sarcopenia Intervention:   Sponsors:   University of Ulster;   Western Health and Social Care Trust Suspended
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsRadiographic vertebral fractures were common among Thai postmenopausal women (~ 29%). These findings suggest that approximately one in three postmenopausal women has undiagnosed vertebral fracture. Radiographic diagnosis should therefore be an essential investigation for identifying and confirming the presence of vertebral fractures.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
Authors: Kang MY, Besley J, Sun T, Paul S Abstract BACKGROUND: Little is known about the prevalence of renal impairment in patients presenting with osteoporotic fractures contraindicating bisphosphonate use in New Zealand, and their eligibility to denosumab. AIM: To assess the prevalence of renal impairment contraindicating bisphosphonate use in older adults presenting with osteoporotic fractures, differences in demographic variables between those with renal impairment and those who do not, and finally to assess eligibility for denosumab based on the current PHARMAC special authority criteria. METHOD: All p...
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Conditions:   Osteoporosis;   Degenerative Lumbar Diseases Intervention:   Sponsor:   Peking University Third Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Vitamin D Status;   Osteoporosis;   Sarcopenia Intervention:   Sponsors:   University of Ulster;   Western Health and Social Care Trust Suspended
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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