Activation of PPAR γ intensified the effect of arsenic trioxide in acute promyelocytic leukemia through the suppression of PI3K/Akt pathway: proposing a novel anticancer effect for pioglitazone.

In conclusion, given the significant efficacy as well as the safety profile of pioglitazone in potentiating the anticancer effect of chemotherapeutic drugs, the present study suggests it as a promising agent to be used in adjuvant strategy for the treatment of APL. PMID: 32169580 [PubMed - as supplied by publisher]
Source: The International Journal of Biochemistry and Cell Biology - Category: Biochemistry Authors: Tags: Int J Biochem Cell Biol Source Type: research