Hope for transplant patients as study finds key to organ scarring

Patients with damaged organs could be helped by new treatments after scientists have discovered how tissues scar. Researchers say that the finding could pave the way for new drugs and eventually reduce the number of patients on organ transplant waiting lists. Fibrotic diseases occur in many tissues within the body - including the liver, lung or kidneys - and have a range of causes including viruses or toxins. Experts say that the main source of scar tissue is found in specialised cells called Myofibroblasts...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Transplants / Organ Donations Source Type: news

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Ronald Reagan UCLA Medical Center led the nation in the number of solid organ transplants performed in 2017, with 641 procedures that included kidney, pancreas, lung, heart and intestine transplants, according to statistics from the Organ Procurement and Transplantation Network.UCLA recorded 363 kidney transplants in 2017, making it the year ’s top kidney transplant center.Other medical centers with a high number of solid organ transplants in 2017 were UC San Francisco; Jackson Memorial Hospital in Miami, Barnes-Jewish Hospital in St. Louis, Missouri; and the University of Wisconsin ’s University Hospital in Ma...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
We presently forget 98% of everything we experience. That will go away in favor of perfect, controllable, configurable memory. Skills and knowledge will become commodities that can be purchased and installed. We will be able to feel exactly as we wish to feel at any given time. How we perceive the world will be mutable and subject to choice. How we think, the very fundamental basis of the mind, will also be mutable and subject to choice. We will merge with our machines, as Kurzweil puts it. The boundary between mind and computing device, between the individual and his or her tools, will blur. Over the course of the ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsOur analysis does not confirm previously reported associations between traffic-related air pollution exposure and the risk of transplant failure.
Source: Journal of Transport and Health - Category: Occupational Health Source Type: research
In this study, senescent cell distribution and quantity in vastus lateralis muscle were examined in young human adults after a single bout of resistance exercise. To determine the effects of dietary protein availability around exercise on senescent cell quantity and macrophage infiltration of skeletal muscle, two isocaloric protein supplements (14% and 44% in calorie) were ingested before and immediately after an acute bout of resistance exercise, in a counter-balanced crossover fashion. An additional parallel trial was conducted to compare the outcome of muscle mass increment under the same dietary conditions after 12 wee...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsOur analysis does not confirm previously reported associations between traffic-related air pollution exposure and the risk of transplant failure.
Source: Journal of Transport and Health - Category: Occupational Health Source Type: research
There has recently been considerable progress in the results of pig organ transplantation in nonhuman primates, largely associated with the availability of (i) pigs genetically engineered to overcome coagulation dysregulation, and (ii) novel immunosuppressive agents. The barriers of thrombotic microangiopathy and/or consumptive coagulation were believed to be associated with (i) activation of the graft vascular endothelial cells by a low level of antipig antibody binding and/or complement deposition and/or innate immune cell activity, and (ii) molecular incompatibilities between the nonhuman primate and pig coagulation-ant...
Source: Transplantation - Category: Transplant Surgery Tags: Reviews Source Type: research
Conclusions Careful documentation of outcomes is needed to ensure ethical practices in selection, informed consent, and postdonation care of this unique donor community.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Conclusions Adenovirus infection is common among pediatric kidney transplant recipients and frequently causes symptomatic disease; however, symptoms are often mild and are not associated with a decline in graft function. Routine monitoring for adenovirus viremia in pediatric kidney transplant recipients may not be warranted.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
es JP Abstract Despite the considerable amount of data available on the effect of donor age upon the outcomes of organ transplantation, these still represent an underutilized resource in aging research. In this review, we have compiled relevant studies that analyze the effect of donor age in graft and patient survival following liver, kidney, pancreas, heart, lung and cornea transplantation, with the aim of deriving insights into possible differential aging rates between the different organs. Overall, older donor age is associated with worse outcomes for all the organs studied. Nonetheless, the donor age from whic...
Source: Experimental Gerontology - Category: Geriatrics Authors: Tags: Exp Gerontol Source Type: research
Conclusions Our analysis does not confirm previously reported associations between traffic-related air pollution exposure and the risk of transplant failure.
Source: Journal of Transport and Health - Category: Occupational Health Source Type: research
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