Multifunctional Acidocin 4356 combats Pseudomonas aeruginosa through membrane perturbation and virulence attenuation: Experimental results confirmed molecular dynamic simulation.

In this study, a new antimicrobial peptide was isolated from Lactobacillus acidophilus ATCC 4356, counteracting both biofilm and planktonic cells of P. aeruginosa. A detailed investigation was then conducted concerning the functional mechanism of this peptide by using fluorescence techniques, electron microscopy, and in silico methods. The antibacterial and antibiofilm properties of this peptide may be important in the treatment of Pseudomonas infections.
PMID: 32169940 [PubMed - as supplied by publisher]

Source: Applied and Environmental Microbiology - March 12, 2020 Category: Microbiology Authors: Modiri S, Kasra Kermanshahi R, Soudi MR, Arab SS, Khammari A, Cousineau B, Vali H, Shahbani Zahiri H, Akbari Noghabi K Tags: Appl Environ Microbiol Source Type: research