Some 'Benign' Breast Masses Pose Greater Cancer Risk Than We Thought

By Gene Emery (Reuters Health) - A type of "benign" mass found in the breast tissue of about 100,000 U.S. women each year poses a greater risk of cancer than previously thought, according to a new review. The mass is classified as atypical hyperplasia, or atypia. Most women who have it - and one out of 10 women who have a breast biopsy do - are usually told that their test result was benign, even though their cells seemed to be exhibiting some early characteristics of a tumor. Doctors may tell those women that they face an above-average risk of cancer so they need to be followed more closely, a recommendation based on the fact that such women are four or five times more likely to develop breast cancer. But that statistic isn't meaningful for a woman who doesn't know what the normal risk is. Researchers have now cast that risk in more concrete terms in the January 1 issue of the New England Journal of Medicine. Women with atypia, they found, have a 7 percent risk of developing a tumor with five years after the biopsy, a 13 percent risk after 10 years and a 30 percent risk after 25 years. Researchers at Vanderbilt University have found a similar risk level. "It gives you the scale of the risk" and it turns out to be a bit higher than the estimated risk that comes from some popular methods used to try to predict a woman's likelihood of developing breast cancer, said Dr. Lynn Hartmann of the Mayo Clinic in Roche...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Conclusions: We found the diagnostic yield of ultrasound screening for breast cancer in high-risk population was satisfactory. Prediction models based on environmental risk factors had limited prediction accuracy and need to be improved in the future. Introduction With an estimate of 2,088,849 newly diagnosed cases in 2018 worldwide, breast cancer is the most frequently diagnosed cancer for women and is also the leading cause of cancer-related deaths (1). In China, the burden of breast cancer increased dramatically for the past decades, with incidence and mortality of 28.77 per 10,000 and 6.35 per 10,000, respectiv...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Very often I encounter women who are far more worried about breast cancer than they are about heart disease. But women have a greater risk of dying from heart disease than from all cancers combined. This is true for women of all races and ethnicities. Yet only about 50% of women realize that they are at greater risk from heart disease than from anything else. Currently in the US, three million women are living with breast cancer, which causes one in 31 deaths. Almost 50 million women have cardiovascular disease, which encompasses heart disease and strokes and causes one in three deaths. Here’s what’s reall...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Breast Cancer Exercise and Fitness Health Healthy Eating Heart Health Women's Health Source Type: blogs
Conclusions: This pilot study indicated that the uptake of gastrin-releasing peptide receptor antagonist 68Ga-NOTA-RM26 may correlate with ER expression in breast cancer. To avoid the physiological uptake of 68Ga-NOTA-RM26 in normal breast tissue, it is suggested that this examination not be performed during the secretory phase of the menstrual cycle. Figure legend: Figure 1. A 60-year-old patient with breast invasive ductal carcinoma showed intense 68Ga-RM26 uptake in the primary tumor (blue arrows) and lymph node metastasis (yellow arrows) on the left side. The tumor stained positively for ER (F) and GRPR (G); the lymph ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Breast Cancer: Novel Tracers, Response Biomarkers, and Therapy Source Type: research
AbstractPurposeTo evaluate the frequency of missed cancers on breast MRI in women participating in a high-risk screening program.MethodsPatient files from women who participated in an increased risk mammography and MRI screening program (2003 –2014) were coupled to the Dutch National Cancer Registry. For each cancer detected, we determined whether an MRI scan was available (0–24 months before cancer detection), which was reported to be negative. These negative MRI scans were in consensus re-evaluated by two dedicated breast radiolog ists, with knowledge of the cancer location. Cancers were scored as invisi...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Author Affiliations open 1Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA 2Social &Scientific Systems, Inc., Durham, North Carolina, USA 3Westat, Durham, North Carolina, USA 4Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway 5Biostatistics and Computational Biology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA PDF Version (548 KB) Abstract About This Article Supplemental Material Bac...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
CONCLUSION: Functional thyroid disorders were not related to MD. However, MD was lower in women with goiter and higher in those reporting Hashimoto's thyroiditis. These relationships should be confirmed in future studies. PMID: 28456099 [PubMed - as supplied by publisher]
Source: Breast - Category: Cancer & Oncology Authors: Tags: Breast Source Type: research
In this study, we compare our automated method to digital MG and a previous reported algorithm for MRI derived BD.Methods From a completed prevention trial, 42 pre- and post-menopausal patients receiving tamoxifen therapy for early stage breast cancer or as primary chemoprevention were identified. Patients had undergone prior digital MG within 6 months from the date of MRI scan and MG-BD was calculated using a well-established method(Cumulus). MRI scans were performed on a 1.5T GE Signa NV-CV/i scanner using an axial radial IDEAL-GRASE sequence to generate quantitative fat fraction maps of the entire breast. Total acquisition time was
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
Conclusion This trial suggests that extending the duration of aromatase inhibitor treatment for postmenopausal women to 10 years, rather than five, may reduce the risk of the cancer recurring or new cancer developing in the other breast. The trial has many strengths, including: a double-blind design, with neither participants nor the research team aware of allocation to treatment or placebo groups – this is regarded as the gold standard of assessing the effect of an intervention; adherence rates to five years were equivalent in both groups (62% in each), suggesting that participants were unaware of treat...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Medication Source Type: news
By Stacy Simon Along with giving Mother's Day gifts and sending greetings this year, encourage the moms in your life to get up to date on cancer screening tests. Screening tests look for cancer before a person has any signs or symptoms. Regular screenings can catch some cancers early, when they’re small, have not spread, and are easier to treat. With cervical and colon cancers, these tests can even prevent cancer from developing in the first place. Sweeten the deal by offering to help your mom schedule her screening, drive her to and from appointments, and keep her company in the waiting room. These are the American ...
Source: American Cancer Society :: News and Features - Category: Cancer & Oncology Tags: Prevention/Early Detection Breast Cancer Cervical Cancer Endometrial Cancer Colon/Rectum Cancer Lung Cancer - Non-Small Cell Source Type: news
February is American Heart Month, a good opportunity to learn the facts about heart disease. The following post was originally published February 2 on HuffPost. In 2015, approximately 370,000 Americans died from heart disease. That’s one in seven deaths. In the time it takes for you to read this article, two more people will die [1]. These statistics are alarming, so what can YOU do? We have an answer: Recognize American Heart Month this February by learning about the signs of coronary artery disease (CAD), the most common form of heart disease. Find out whether that huffing and puffing you experience while walking u...
Source: Disruptive Women in Health Care - Category: Consumer Health News Authors: Tags: Chronic Conditions Women's Health Source Type: blogs
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