Cancers, Vol. 12, Pages 693: Imaging Features and Patterns of Metastasis in Non-Small Cell Lung Cancer with RET Rearrangements

Cancers, Vol. 12, Pages 693: Imaging Features and Patterns of Metastasis in Non-Small Cell Lung Cancer with RET Rearrangements Cancers doi: 10.3390/cancers12030693 Authors: Subba R. Digumarthy Dexter P. Mendoza Jessica J. Lin Marguerite Rooney Andrew Do Emily Chin Beow Y. Yeap Alice T. Shaw Justin F. Gainor Rearranged during transfection proto-oncogene (RET) fusions represent a potentially targetable oncogenic driver in non-small cell lung cancer (NSCLC). Imaging features and metastatic patterns of advanced RET fusion-positive (RET+) NSCLC are not well established. Our goal was to compare the imaging features and patterns of metastases in RET+, ALK+ and ROS1+ NSCLC. Patients with RET+, ALK+, or ROS1+ NSCLC seen at our institution between January 2014 and December 2018 with available pre-treatment imaging were identified. The clinicopathologic features, imaging characteristics, and the distribution of metastases were reviewed and compared. We identified 215 patients with NSCLC harboring RET, ALK, or ROS1 gene fusion (RET = 32; ALK = 116; ROS1 = 67). Patients with RET+ NSCLC were older at presentation compared to ALK+ and ROS1+ patients (median age: RET = 64 years; ALK = 51 years, p < 0.001; ROS = 54 years, p = 0.042) and had a higher frequency of neuroendocrine histology (RET = 12%; ALK = 2%, p = 0.025; ROS1 = 0%, p = 0.010). Primary tumors in RET+ patients were more likely to be peripheral (RET = 69%; ALK = 47%, p = 0.029; ROS1 = 36%, p = 0....
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research