N-glycosylation of blood coagulation factor XIII subunit B and its functional consequence.

CONCLUSION: Characterization of the glycan moieties attached to FXIII-B is reported for the first time. Complete deglycosylation of the native protein was achieved by a deglycosylation workflow. The associated glycan structure is not required for FXIII-B dimer formation, but it very likely prolongs the half-life of FXIII-B in the plasma.
PMID: 32168410 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - March 12, 2020 Category: Hematology Authors: Hurják B, Kovács Z, Döncző B, Katona É, Haramura G, Erdélyi F, Shemirani AH, Sadeghi F, Muszbek L, Guttman A Tags: J Thromb Haemost Source Type: research