Depot-specific analysis of human adipose cells and their responses to Bisphenol S.
In this study, we show that human primary progenitors from omental depots have a distinct transcriptomic signature as compared to progenitors derived from donor-matched subcutaneous depots. Furthermore, we show that BPS increases adipogenesis of both omental and subcutaneous preadipocytes and can mimic the action of glucocorticoids or peroxisome proliferator-activated receptor γ (PPARγ) agonists. We also show that BPS treatment, at 0.1 µM and 25 µM, modifies the adipokine profiles of both omental and subcutaneous derived adipocytes, in a depot specific manner. Taken together our data show distinct gene expression profiles in the omental versus subcutaneous progenitors and similar responses to the BPA analogue, BPS.
PMID: 32170302 [PubMed - as supplied by publisher]
Source: Endocrinology - Category: Endocrinology Authors: Peshdary V, Styles G, Gagné R, Yauk CL, Sorisky A, Atlas E Tags: Endocrinology Source Type: research
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