Further considerations towards an effective and efficient oncology drug discovery DMPK strategy.

CONCLUSION: Application of our updated drug-drug interaction and central nervous system drug exposure strategies are exemplified, as is the impact of physiologically based pharmacokinetic and pharmacokinetic-pharmacodynamic modelling, for human predictions.
PMID: 32164508 [PubMed - as supplied by publisher]

Source: Current Drug Metabolism - March 10, 2020 Category: Drugs & Pharmacology Authors: Williamson B, Colclough N, Fretland A, Jones B, Owen R, McGinnity D Tags: Curr Drug Metab Source Type: research