Clinicopathologic and molecular aspects of high-grade neuroendocrine carcinoma of the uterine cervix: emphasis on novel chemotherapeutic strategies

High-grade neuroendocrine carcinomas (HGNEC) of the cervix are rare and carry an extremely poor prognosis. Fortunately, there have been recent advances in our molecular understanding of these carcinomas and some advances offer novel therapeutic options. The vast majority of HGNEC of the cervix are associated with human papillomavirus (HPV) and would be prevented by currently available vaccines. TP53 mutations are variably identified and likely drive a second pathway, one unrelated to high-risk HPV.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Mini-symposium: Endocrine pathology Source Type: research