Evaluation of in vivo anti-inflammatory and anti-angiogenic attributes of methanolic extract of Launaea spinosa

This study was conducted to evaluate anti-inflammatory and anti-angiogenic activities of methanol extract ofLaunaea spinosa. Extraction was performed by maceration and the resultant green coloured extract was labelled asLs.Me. Solubility analysis showed thatLs.Me was miscible with distilled water, normal saline, ethanol and methanol. Metal analysis following acid digestion method exhibited the presence of copper, magnesium, manganese, iron, zinc and calcium. Phytochemical analysis confirmed the presence of different classes of secondary metabolites inLs.Me. HPLC analysis showed the presence of quercetin, gallic acid, caffeic acid, benzoic acid and sinapic acid inLs.Me. Data of in vitro antioxidant assays showed moderate antioxidant potential ofLs.Me which was also confirmed by data of in vivo enzymes (SOD, CAT, and TSP)  assays. Antimicrobial assays data showed thatLs.Me was active againstS.aureus andS.epidermidis (bacterial) as well asC.albicans andA.niger (fungal) strains. Data of acute physio-pathological studies showed no abnormalities in Albino rats up to the dose of 2000  mg/kg ofLs.Me. Acute and chronic inflammatory models were used to evaluate anti-inflammatory effects ofLs.Me. Data of acute studies showed thatLs.Me has the potential to arrest inflammation produced by different mediators in a dose-dependent manner. 200  mg/kg ofLs.Me was found to produce significantly (p 
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research

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Stroke is a neurologic disorder considered the first cause of disability worldwide due to motor, cognitive, and sensorial sequels. Balance dysfunctions in stroke survivors increase the risk of falls and physiotherapeutic rehabilitation is essential to redu...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Publication date: Available online 24 May 2020Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Maira Jaqueline da Cunha, Katia Daniele Rech, Ana Paula Salazar, Aline Souza Pagnussat
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
Authors: Sucuoglu H Abstract PURPOSE: To investigate the effects of robot-assisted gait training (RAGT) alongside conventional therapy on the standing and walking abilities of children with cerebral palsy (CP). METHODS: The study sample consisted of children (aged 4-18 years) with CP whose gross motor function classification system (GMFCS) was at levels I-V. In total, 75 children with CP were evaluated and 38 patients completed the study. Patients were divided into two groups as GMFCS levels I-III (Group 1) and levels IV-V (Group 2). RAGT (30 min/session) and conventional physiotherapy (30 min/session) were app...
Source: Journal of Pediatric Rehabilitation Medicine - Category: Rehabilitation Tags: J Pediatr Rehabil Med Source Type: research
CONCLUSION: An intensive, multidisciplinary, hospital-based rehabilitation programme was associated with improvements in the great majority of patients with TOS - even after private-practice physiotherapy had failed. PMID: 32444532 [PubMed - as supplied by publisher]
Source: Journal of Back and Musculoskeletal Rehabilitation - Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research
ConclusionsRT seems to be an effective means to improve CoD speed in youth and young physically active and athletic adults. Our findings indicate that the impact of RT on CoD speed may be more prominent in males than in females and in youth than in adults. Additionally, independently computed single factor analyses for different training variables showed that higher compared with lower RT intensities, frequencies, and volumes appear not to have an advantage on the magnitude of CoD speed improvements. In terms of RT type, similar improvements were observed following machine-based and free weights training.
Source: Sports Medicine - Category: Sports Medicine Source Type: research
CONCLUSIONS: The results indicate a heterogeneous indexation of the included journals. Only a small number is indexed in common international literature databases such as MEDLINE or CINAHL. On the other hand, only a few journals are not indexed in any database. The results can be used as a basis to define databases for literature searches as part of systematic reviews. In addition, the findings might guide the selection of journals for hand searching after literature databases have been defined. PMID: 32439423 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research
Differences in physiotherapy intervention practices for mastitis have been shown across Australian regions and facilities and it is unknown if this is associated with physiotherapists ’ definition and diagnosis...
Source: International Breastfeeding Journal - Category: Nursing Authors: Tags: Research Source Type: research
Objective The aim of the study was to assess the effects of elastic taping on pain, physical function, range of motion, and muscle strength in patients with knee osteoarthritis. Design We searched the PubMed, the Cochrane Central Register of Controlled Trials, Web of Science, Physiotherapy Evidence Database, Scopus, EMBASE, OVID, CNKI, and WANFANG to identify relevant randomized controlled trials. The primary outcome measures were pain and physical function. The secondary outcome measures were range of motion and muscle strength. Results Eleven randomized controlled trials involving 490 patients with knee osteoarth...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
Publication date: Available online 22 May 2020Source: Physiology &BehaviorAuthor(s): Lauren N. Woodie, Claire E. Neinast, William Haynes, Bulbul Ahmed, Emily C. Graff, Michael W. Greene
Source: Physiology and Behavior - Category: Physiology Source Type: research
Abstract OBJECTIVE: Instrumented fusion of lumbar motion segments using a minimally invasive technique. INDICATIONS: Degenerative disc disease, segmental degeneration, degenerative spondylolisthesis, isthmic spondylolisthesis, pseudarthrosis, other spinal lumbar instabilities, disc prolapse, revision for failed back surgery syndrome, unilateral neuroforaminal stenosis, facet joint arthrosis. CONTRAINDICATIONS: High-grade spondylolisthesis (Meyerding grades III/IV, spondyloptosis), bilateral nerve root compression, vertebral fractures, tumors, high-grade spinal instabilities, primary spinal defo...
Source: Operative Orthopadie und Traumatologie - Category: Orthopaedics Authors: Tags: Oper Orthop Traumatol Source Type: research
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