Flow Profile Characteristics in Fontan Circulation are Associated with the Single Ventricle Dilation and Function: Principal Component Analysis Study.

Flow Profile Characteristics in Fontan Circulation are Associated with the Single Ventricle Dilation and Function: Principal Component Analysis Study.
Am J Physiol Heart Circ Physiol. 2020 Mar 13;:
Authors: Schäfer M, Frank BS, Humphries SM, Hunter KS, Carmody KL, Jacobsen R, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Barker AJ, Browne L, Ivy DD, Younoszai A, Di Maria MV
Abstract
The Fontan circulation is characterized as a non-pulsatile flow propagation without a pressure generating ventricle. However, flow through the Fontan circulation still exhibits oscillatory waves as a result of pressure changes generated by the systemic single ventricle. Identification of discrete flow patterns through the Fontan circuit may be important to understand single ventricle performance. 97 patients with Fontan circulation underwent phase-contrast MRI of the right pulmonary artery yielding subject specific flow wave-forms. Principal component analysis was performed on pre-processed flow-waveforms. Principal components were then correlated with standard MRI indices of function, volume, and aorto-pulmonary collateral flow. The 1st principal component (PC) described systolic vs. diastolic dominant flow through the Fontan circulation accounting for 31.3% of the variance in all wave-forms. The first PC correlated with end-diastolic volume (r=0.34,P=0.001), and end-systolic volume (r=0.30,P=0.003), cardiac index (r=0.51, P<0.001) and the amount of a...

Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2020 Category: Physiology Authors: Schäfer M, Frank BS, Humphries SM, Hunter KS, Carmody KL, Jacobsen R, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Barker AJ, Browne L, Ivy DD, Younoszai A, Di Maria MV Tags: Am J Physiol Heart Circ Physiol Source Type: research