Echocardiographic Parameters During and Beyond Onset of Kawasaki Disease Correlate with Onset Serum N-Terminal pro-Brain Natriuretic Peptide (NT-proBNP)

The objective of this study is to examine the relationship between serum values of NT-proBNP at time of KD diagnosis with cardiac systolic, diastolic function and electrocardiographic changes, at onset of the disease and during the first year of follow-up. KD was diagnosed in 127 children between March 2007 and July 2014, mean diagnostic age 3.5  ± 2.9 years. Coronary artery maximumz score was 2.6  ± 2.8 (range − 0.6 to + 18.9), with giant aneurysm in 5/122 (4.1%). Age-adjusted NT-proBNP was 2.6 ± 1.6z score, 78/122 (63.9%)  >  2.0. There was a crescendo correlation between onset NT-proBNPz score and C-Reactive protein (CRP) serum levels (slope  + 0.49,p <  0.001). There was a crescendo correlation between NT-proBNPz score and indexed left ventricular (LV) mass (slope  + 1.86,p = 0.02), LV diastolic function parameterE/e′ ratio (slope + 0.31,p = 0.04) and a decrescendo correlation with age-adjusted LV shortening fraction (SF) (− 0.63,p = 0.02). Lower SFz score, higher left ventricular mass index andE/e ′ ratio were associated with higher NT-proBNPzscore, but without correlation with CRP levels. Within 2 –3 months from the onset of the disease, there was a resolution of the systolic dysfunction. Electrocardiographic parameter changes were associated with decreased LV shortening fraction but not with NT-proBNP. KD patients with elevated NT-proBNP at onset have sub-clinical myocardial involvement a nd might b...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research