Title: Potential Mitochondrial Toxicants: Tox21 Screen Identifies Chemicals of Interest

Carol Potera, based in Montana, also writes for Microbe, Genetic Engineering News, and the American Journal of Nursing. About This Article open Citation: Potera C. 2015. Potential mitochondrial toxicants: Tox21 identifies chemicals of interest. Environ Health Perspect 123:A23; http://dx.doi.org/10.1289/ehp.122-A23 News Topics: Biochemistry, Chemical Testing, High-Throughput Screening, Molecular Biology Published: 1 January 2015 PDF Version (946 KB) Related EHP Article Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential Matias S. Attene-Ramos, Ruili Huang, Sam Michael, Kristine L. Witt, Ann Richard, Raymond R. Tice, Anton Simeonov, Christopher P. Austin, and Menghang Xia Mitochondria have many important functions, including production of adenosine triphosphate (ATP) to fuel cells and regulation of cell growth, signaling, differentiation, and apoptosis.1 Disrupted mitochondrial function raises the potential for health effects and in fact has been associated with cancer, diabetes, cardiovascular disease, and autism.2,3 In a study reported this month in EHP, investigators with the Tox21 consortium assessed the impact of more than 8,300 chemicals on mitochondrial activity.4 Tox21, short for Toxicology in the 21st Century, is a collaboration of federal entities including the National Toxicology Program, the Environmental Protection Agency, the Food and Drug Administrat...
Source: EHP Research - Category: Environmental Health Authors: Tags: Featured News Science Selection Biochemistry Chemical Testing High-Throughput Screening January 2015 Molecular Biology Source Type: research