Cardiovascular and diabetes healthcare in patients with schizophrenia

Schizophrenia is a severe and persistent mental illness associated with early mortality and a higher rate of medical comorbidity compared to the general population. Individuals with schizophrenia are at risk of healthcare disparities including reduced access to primary care and suboptimal health maintenance interventions. Barriers to care can include impairment communicating with healthcare providers, the stigma of psychiatric disease, and a poor understanding of medical condition and need for treatment all of which can delay diagnosis and timely treatment.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Poster Number: EI-60 Source Type: research

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By Emma Young We all know that too little sleep is bad for us. Matthew Walker, a UC Berkeley sleep scientist and author of the best-selling Why We Sleep, has gone so far as to declare: “The shorter you sleep, the shorter your life.” However, some researchers fear that our concerns about not getting enough sleep are becoming overblown — and that, ironically, they could be making the problem worse. In this feature, we take a look at evidence that “too little” sleep isn’t always the disaster that it’s held up to be. It’s not always about a lack of sleep You’ll be fami...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Feature Sleep and dreaming Source Type: blogs
This study aimed to investigate zolpidem overutilisation among Korean patients with insomnia. We analysed the National Patient Sample (NPS) data compiled by the Health Insurance Review &Assessment Service (HIRA-NPS) in 2016. Zolpidem overutilisation was defined as when a patient used zolpidem for longer than 30 consecutive days and prescriptions overlapped with more than 10% of total prescription periods. Demographic and clinical factors associated with the overutilisation of zolpidem were investigated using a logistic regression model. The proportion of zolpidem overutilisers was estimated at 5.0%. Factors such as age...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
This study aims to determine if SCZ patients are at increased risk of incident OSA.MethodsA total of 5092 newly diagnosed SCZ patients and 5092 non-SCZ controls matched by gender, age, and index year were included between 2000 and 2012 and followed to 2013. Participants newly diagnosed with OSA were defined as incidents. Cox regression analysis was used to calculate the hazard ratio (HR) with 95% confidence intervals (CI) of the OSA incidence rate between the two groups studied.ResultsSCZ patients were at increased risk of OSA compared to non-SCZ controls after adjusting for gender, age, comorbidities, and duration of anti...
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
CONCLUSION: PIM use is highly prevalent among older individuals with diabetes. Interventions to promote optimal medication use should particularly target individuals with comorbidities and polypharmacy who are most vulnerable to adverse drug events. PMID: 32402848 [PubMed - as supplied by publisher]
Source: Primary Care - Category: Primary Care Authors: Tags: Prim Care Diabetes Source Type: research
Conclusions The present study suggests that presence of diabetes mellitus should not stop the clinicians to use clozapine among patients with schizophrenia. However, close monitoring of blood glucose levels must be done.
Source: Journal of Clinical Psychopharmacology - Category: Psychiatry Tags: Original Contributions Source Type: research
CONCLUSION: The results of the present study suggest that multi-systemic mitochondrial dysfunction may be an underlying mechanism involved in schizophrenia. PMID: 32329429 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research
Genome-wide association studies (GWAS) have identified abundant risk loci associated with schizophrenia (SCZ), cardiometabolic disease (CMD) including body mass index, coronary artery diseases, type 2 diabetes, low- and high-density lipoprotein, total cholesterol, and triglycerides. Although recent studies have suggested that genetic risk shared between these disorders, the pleiotropic genes and biological pathways shared between them are still vague. Here we integrated comprehensive multi-dimensional data from GWAS, expression quantitative trait loci (eQTL), and gene set database to systematically identify potential pleio...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
AbstractAripiprazole, brexpiprazole and cariprazine differ from all other second-generation antipsychotics due to partial agonism at the dopamine D2 and D3 receptors. In contrast to aripiprazole, brexpiprazole has lower intrinsic dopamine D2 activity and higher affinity for the serotonin 5-HT1A and 5-HT2A receptors, while cariprazine has the highest affinity for the dopamine D3 receptor, and the longest half-life. The main adverse effect of dopamine receptor partial agonists (DRPAs) is akathisia of low-to-moderate severity, which occurs in a small proportion of patients, usually in the first few weeks of treatment. While d...
Source: CNS Drugs - Category: Neurology Source Type: research
In conclusion, metabolic disorder in the pregnancy, dif ficulties in childbirth and specific family phenotype were related to ADHD, specifically with hyperactive–impulsive presentation, but not in subclinical ADHD.
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
CONCLUSION: Early recognition and accurate diagnosis of BD, which enables adequate and timely treatment, can improve outcomes. PMID: 32125440 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research
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