Trial of dronabinol adjunctive treatment of agitation in alzheimer's disease (ad) (thc-ad)

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease of aging. Neuropsychiatric symptoms (NPS) in AD are a major cause of burden to patients, caregivers, and society and are near-universal at some point in the AD course. One of the most troubling of these symptoms is agitation (Agit-AD), typified by a variety of problem behaviors including combativeness, yelling, pacing, lack of cooperation with care, insomnia, and restlessness. There is a great need for better interventions that target Agit-AD, a major source of patient disability as well as caregiver burden and stress, particularly in the case of moderate to severe agitation.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Poster Number: NR - 2 Source Type: research

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Publication date: Available online 24 May 2020Source: PhytomedicineAuthor(s): Hai-Qiao Wang, Min Liu, Liang Wang, Fen Lan, Yi-Han Zhang, Jin-Er Xia, Zhen-Dong Xu, Hai Zhang
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Publication date: August 2020Source: Research in Developmental Disabilities, Volume 103Author(s): Christina L. Hancock
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
DEMENTIA currently has no cure, but scientists have been looking into ways different types of dementia can be prevented. In a new study, three foods have been shown to have protective benefits against Alzheimer's disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
HDAC1 is involved in a form of DNA repair, but levels decline with age, as well as in Alzheimer's disease. This leads to a greater accumulation of unrepaired oxidative DNA damage in neurons. Researchers here note that increased activation of HDAC1 appears to improve cognitive function via a reduction in this oxidative DNA damage. An HDAC1 activator drug has been tested as a treatment for dementia, but caused serious side-effects. Better compounds or other approaches may be able to obtain similar benefits without the harms. There are several members of the HDAC family of enzymes, and their primary function is to m...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusions: Lifestyle factors, such as physical activity, sleep, and social activity appear to be associated with cognitive function among older people. Physical activity and appropriate durations of sleep and conversation are important for cognitive function. Introduction Dementia is a major public health issue worldwide, with a serious burden for patients, caregivers, and society, as well as substantial economic impacts (1). Although the prevalence of late-life cognitive impairment and dementia are expected to increase in future, effective disease-modifying treatments are currently unavailable. Therefore, unders...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionsDifferent patterns of sleep disturbances are observed in HD patients: insomnia, difficulties in falling asleep, frequent nocturnal awakenings, and excessive daytime sleepiness are the most common sleep problems reported by patients with HD. In several HD studies, specific changes in sleep architecture and in circadian melatonin secretion were identified in laboratory testing.Sleep disorders in HD have diverse and complex determinants, the most significant of which includes damage to brain areas that are responsible for the proper sleep pattern and circadian rhythm regulation. Sleep and circadian rhythm disorders...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Authors: Jang JH, Jung K, Kim JS, Jung I, Yoo H, Moon C Abstract Parkinson's disease (PD), the second most common progressive neurodegenerative disorder, is characterized by complex motor and nonmotor symptoms. The clinical diagnosis of PD is defined by bradykinesia and other cardinal motor features, although several nonmotor symptoms are also related to disability, an impaired quality of life, and shortened life expectancy. Levodopa, which is used as a standard pharmacotherapy for PD, has limitations including a short half-life, fluctuations in efficacy, and dyskinesias with long-term use. There have been efforts ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Objective:The goal of this retrospective study was to evaluate whether long-term use of slow-wave sleep (SWS) enhancers relates to delayed cognitive decline.Background:In humans, SWS mediates episodic memory consolidation. Recent studies indicate that activity-dependent amyloid accumulation in mice worsens with SWS restriction and improves with SWS enhancement. Furthermore, patients with Alzheimer’s disease have less SWS, and cognitively non-impaired adults with decreased SWS exhibit increased amyloid burden. We hypothesized that long-term SWS enhancement may relate to delayed cognitive decline, and focused on trazod...
Source: Neurology - Category: Neurology Authors: Tags: Aging, Dementia, Behavioral and Cognitive Neurology ePoster Session I Source Type: research
— Hundreds of companies around the globe, now including Elon Musk’s Neuralink and even Facebook,  are researching and developing new ways to help brain owners be smarter, sharper, and healthier. What explains this flurry of activity? Where may it be headed? To help you understand what’s going on, let me highlight five key facts that emerged from the recent SharpBrains Virtual Summit, where 200+ participants in 16 countries shared and discussed the latest about neurotech­nolo­gy, brain health and digital health.   Fact 1. There are 7.5 billion human brains out there, a...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology Akili Baycrest Brain-health BrainHQ Claritas Mindsciences Click Therapeutics cogmed Cogniciti cognifit digital health Educational Testing Service Elon Musk Facebook Headsp Source Type: blogs
Growing up a musically-obsessed child in the 80's, Daryl Hall was one of my biggest inspirations. A masterful, inventive songwriter with an ocean of soul, he set me on the path to being an artist, to never waste a word, and to sing because I mean it. With six number ones and five additional top ten hits throughout the 70's and 80's Daryl Hall and John Oates are the number one duo in music history. Still at the top of his game at 69 years old, Daryl has won legions of new fans with his hit MTV Live show Live From Daryl's House. In February of 2015, at my very sickest from chronic Lyme and Bartonella, after it was missed b...
Source: Science - The Huffington Post - Category: Science Source Type: news
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