Lack of evidence for CDK12 as an ovarian cancer predisposing gene

AbstractCDK12 variants were investigated as a genetic susceptibility to ovarian cancer in a series of 416 unrelated and consecutive patients with ovarian carcinoma and who carry neither germlineBRCA1 norBRCA2 pathogenic variant. The presence ofCDK12 variants was searched in germline DNA by massive parallel sequencing on pooled DNAs. The lack of detection of deleterious variants and the observed proportion of missense variants in the series of ovarian carcinoma patients as compared with all human populations strongly suggests thatCDK12 is not an ovarian cancer predisposing gene.
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research