Living with werewolf syndrome: Mother and children undergo laser treatment

Devi Budhathoki, 38, and her children Manjura, 14, and Niraj, 12, from a remote village in northern Nepal suffers from Congenital Hypertrichosis Lanuginosa.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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We report a 74-year-old male presented to an outpatient dermatology clinic in Manaus, Amazonas, with a one-year history of pruritic, keloidal lesions on his left lower extremity. Histopathology showed round structures in reticular dermis. Grocott methenamine silver stain revealed numerous round yeasts with thick double walls, occurring singly or in chains connected by tubular projections. The diagnosis was lobomycosis. Although the keloidal lesions presented by this patient are typical of lobomycosis, their linear distribution along the left lower limb is unusual.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Sema Turker, Ebru Cilbir, Cengiz Karacin, Mustafa AltinbasJournal of Cancer Research and Therapeutics 2020 16(3):690-692 Anti-epidermal growth factor receptor (EGFR) antibodies are mainly used in the treatment of advanced stages of solid tumors as a targeted therapy to inhibit tumor proliferation. They cause many dermatological adverse reactions through inhibition of EGFR pathway in the skin. A 39-year-old female patient diagnosed with metastatic colon adenocarcinoma received oxaliplatin, fluorouracil, and folinic acid regimen with cetuximab. The patient noticed increase in fairy hair especially at facial area as well as ...
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Abstract Epidermal growth factor receptor inhibitors (EGFRi) are used for a variety of solid malignancies. Cutaneous adverse events are common, and include papulopustular eruptions (PPEs) in up to 90% of patients, xerosis, mucositis, paronychia, hypertrichosis, and enhanced radiation dermatitis.1-3 Here, we present a novel case series of eight patients who developed erythema dyschromicum perstans (EDP)-like eruptions while receiving EGFRis. PMID: 32652530 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Conclusion: In children with severe hypothyroidism, the most sensitive symptoms are growth arrest and weight gain despite the fact that, in some children, the auxological parameters at presentation could be within normal values for the population. The specific biochemical profile closely correlates to the severity of thyroid hormone deficiency and involves mostly erythropoiesis, liver function, and kidney function. Pituitary enlargement should be considered in each child with severe hypothyroidism. It is necessary to conduct prospective studies evaluating the actual frequency of anti-TSHR antibodies and pituitary enlargeme...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Cantú syndrome versus Zimmermann-Laband syndrome: Report of nine individuals with ABCC9 variants. Eur J Med Genet. 2020 Jul 02;:103996 Authors: Kortüm F, Niceta M, Magliozzi M, Kubat KD, Robertson SP, Moresco A, Dentici ML, Baban A, Leoni C, Onesimo R, Obregon MG, Digilio MC, Zampino G, Novelli A, Tartaglia M, Kutsche K Abstract Cantú syndrome (CS) is a rare developmental disorder characterized by a coarse facial appearance, macrocephaly, hypertrichosis, skeletal and cardiovascular anomalies and caused by heterozygous gain-of-function variants in ABCC9 and KCNJ8, encoding heteroocta...
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research
We report a case of 22-month-old female child presenting to us with severe failure to thrive, dysmorphic features, hirsutism, external ophthalmoplegia epilepsy, and neuroregression with characteristic findings of Leigh’s syndrome on neuroimaging and her muscle biopsy revealed evidence of mitochondrial respiratory chain defect involving complex IV and SURF1 mutation.
Source: Journal of Pediatric Neurosciences - Category: Neuroscience Authors: Source Type: research
Abstract Segmental odontomaxillary dysplasia (SOD) is a rare condition of unknown incidence, with approximately 60 cases reported (as reviewed in 2018)1 . It presents at birth or during childhood with a constellation of ipsilateral facial signs: non-progressive/slowly-progressive overgrowth or undergrowth of soft tissues and/or bones (typically centred on the posterior maxilla, and leading to facial asymmetry), dental anomalies (missing teeth or abnormal dentition), gingival hyperplasia or abnormal gingivae, commissural lip fissures, hypertrichosis, cutaneous hyperpigmentation and/or erythema, cutaneous depression...
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
ConclusionThe authors describe a new laser technique for depigmentation and epilation and their experience in the treatment of CMN with hypertrichosis. Data collected in this study showed first of all an extreme safety and tolerability of the procedure in children and young patients, with no adverse effects such as skin atrophy, pathological scarring and aesthetic improvement.Level of evidence: Level I, therapeutic; risk/prognostic study.
Source: European Journal of Plastic Surgery - Category: Cosmetic Surgery Source Type: research
A 56-year-old woman with no history of comorbidities or medication intake presented with a 1-year history of blisters and erosions affecting the dorsum of the hands, forearms, cheeks, and forehead. She complained of pain and burning at those sites, and lesions were refractory to potent topical corticosteroids and antibiotics. On physical examination, she had a localized eruption consisting of erosions, blisters, and milia on the dorsum of hands (Figure 1A). On the face, she presented with erosions and mild hypertrichosis.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
A 56-year-old woman with no history of comorbidities or medication intake presented with a 1-year history of blisters and erosions affecting dorsum of the hands, forearms, cheeks, and forehead. She complained of pain and burning at those sites and lesions were refractory to potent topical corticosteroids and antibiotics. On physical examination, she had a localized eruption consisting of erosions, blisters, and milia on the dorsum of hands (Figure 1). On the face, she presented with erosions and mild hypertrichosis.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
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