Antidepressant-like effects of kynurenic acid in a modified forced swim test.
CONCLUSIONS: The results demonstrated, for the first time, the presence of antidepressant-like effects of KYNA in a modified mouse FST. Furthermore, modified combination FST showed that the antidepressant-like actions of KYNA strongly interacted with 5-hydroxytryptamine type 2 SER-ergic receptors, weakly interacted with D2, D3, D4 DA-ergic receptors, and interacted moderately with GABAA receptors.
PMID: 32162182 [PubMed - as supplied by publisher]
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Tanaka M, Bohár Z, Martos D, Telegdy G, Vécsei L Tags: Pharmacol Rep Source Type: research
More News: Alzheimer's | Brain | Depression | Drugs & Pharmacology | Huntington's Disease | Inderal | Neurology | Parkinson's Disease | Psychology | Schizophrenia | Study