Screening practices for nontuberculous mycobacteria at us cystic fibrosis centers

Cystic Fibrosis (CF) is a condition known to have chronic infection of the airways with persistent and excessive inflammation, and abnormally thickened airway secretions leading to bronchiectasis [1]. Persons with CF are preferentially susceptible to certain chronic pathogens such as methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Burkholderia cepacia, Stenotrophomonas maltophilia among others [2 –5]. Nontuberculous mycobacteria (NTM) species have recently risen in significance because of recognition of increased prevalence and perceived pathogenicity [6–10].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research

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Authors: Grette K, Cassity S, Holliday N, Rimawi BH Abstract We performed a comprehensive systematic review of acute pyelonephritis in pregnancy using PubMed, SCOPUS, ClinicalTrials.gov, and Ovid from inception to April 2018. About 7796 references were screened for inclusion, and 52 references from 1908 to 2017 were included. One hundred seven cases of acute pyelonephritis in pregnant women were reviewed. Gestational age at diagnosis was reported as 2 (2%), 43 (40%), and 51 (52%) during the first, second, and third trimesters, respectively. Maternal complications included sepsis (49%), acute respiratory distress sy...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
Publication date: Available online 9 July 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Amjed Alabresm, Yung Pin Chen, Savannah Wichter-Chandler, Jamie Lead, Brian C. Benicewicz, Alan W. Decho
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: 30 August 2020Source: International Journal of Pharmaceutics, Volume 586Author(s): Heba A. Fathi, Ayat Abdelkader, Mahmoud S. AbdelKarim, Ayman A. Abdelaziz, Mohamed A. El Mokhtar, Ayat Allam, Gihan Fetih, Mahmoud El Badry, Mahmoud Elsabahy
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days. BMC Pharmacol Toxicol. 2020 Jul 08;21(1):50 Authors: Ueda T, Takesue Y, Nakajima K, Ichiki K, Ishikawa K, Takai Y, Yamada K, Tsuchida T, Otani N, Takahashi Y, Ishihara M, Takubo S, Ikeuchi H, Uchino M, Kimura T Abstract BACKGROUND: A trough concentration (Cmin) ≥20 μg/mL of teicoplanin is recommended for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infecti...
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
FRIDAY, July 10, 2020 -- If you're a fan of raw milk, keep it chilled. Leaving raw milk at room temperature can release antimicrobial-resistant genes, a new study suggests. Also, bacteria that have antimicrobial-resistant genes can transfer them to...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
The Journal of Organic ChemistryDOI: 10.1021/acs.joc.0c01004
Source: The Journal of Organic Chemistry - Category: Chemistry Authors: Source Type: research
Publication date: Available online 9 July 2020Source: Chinese Chemical LettersAuthor(s): Xiaoqi Tao, Liao Ziyi, Zhang Yaqing, Fu Fei, Hao Mengqi, Song Yang, Song Erqun
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Pleckstrin homology domain–containing A7 (PLEKHA7) is a cytoplasmic protein at adherens junctions that has been implicated in hypertension, glaucoma, and responses to Staphylococcus aureus α-toxin. Complex formation between PLEKHA7, PDZ domain–containing 11 (PDZD11), tetraspanin 33, and the α-toxin receptor ADAM metallopeptidase domain 10 (ADAM10) promotes junctional clustering of ADAM10 and α-toxin–mediated pore formation. However, how the N-terminal region of PDZD11 interacts with the N-terminal tandem WW domains of PLEKHA7 and how this interaction promotes tetraspanin 33 binding to th...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Cell Biology Source Type: research
Conclusions: The pattern of airway colonisation in the Indian setting is different from the Caucasian population, and P. aeruginosa and Burkholderia cepacia complex appear early. Colonisation with P. aeruginosa benefits from therapy. In case of infection, care must be taken while initiating empiric therapy. It should be based on local antibiograms to prevent the emergence of resistant microbes.
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
ConclusionThere was a high correlation between pretransplant sinus cultures and posttransplant BAL cultures for PsA, MRSA, and Burkholderia sp. This suggests that the paranasal sinuses may act as a reservoir for allograft colonization in patients with cystic fibrosis. Further studies are needed to determine whether treatment of sinusitis affects allograft colonization and transplant outcomes.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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