Rise in breast cancer fueled by more than later pregnancy, lower birth rate

Rising breast cancer rates in the U.S. during the last 40 years have long been linked with women opting to have children later in life, if at all. An analysis published Friday, however, challenges that idea.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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(Cold Spring Harbor Laboratory) Women who are pregnant before the age of 25 have a decreased risk of breast cancer throughout their lives. Searching for the mechanism behind this life-saver, CSHL researchers discovered that pregnancy reprograms the breast cells to turn off a cancer gene and turn on a gene that arrests cell growth.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
i Shalgi Ben-Aharon Breast cancer is diagnosed in ~0.3% of pregnant women. Studies that have addressed gestational and neonatal outcomes of chemotherapy during pregnancy have demonstrated increased gestational complications including preeclampsia and intrauterine growth retardation. We hypothesized that anthracycline-induced gestational complications could be derived from direct toxicity on the placenta vasculature. Pregnant ICR mice (day E12.5) were treated with doxorubicin (DXR; 8 mg/kg) or saline, while their umbilical cord blood flow was imaged by pulse-wave (PW) Doppler. Mice were euthanized on day E18.5, an...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
RARITAN, NJ, May 13, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today results from the final analysis of the pivotal Phase 3 SPARTAN study demonstrating ERLEADA® (apalutamide) in combination with androgen deprivation therapy (ADT) significantly improved overall survival (OS), compared to ADT alone, in patients with non-metastatic castration-resistant prostate cancer (nmCRPC) who were at high risk of developing metastases.[i] Results will be presented at the American Society of Clinical Oncology (ASCO) Virtual Scientific Program (Abstract #5516) beginning May 29th. ERLEADA® i...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
In this study, the expression of FGF3, FGFR2, STAT3, p-STAT3Tyr705, and p-STAT3Ser727 was detected in serum and normal mammary gland tissues of TA2 mice with different number of pregnancies and SBC. The proliferation, invasiveness, and migration abilities of MA-891 cells from TA2 SBC were compared before and after cryptotanshinone and Stattic treatment. Transient siRNA transfection was used to detect the invasiveness, and migration abilities to avoid the off-targets effects. Downstream protein expression of STAT3 was also detected in MA-891 cells and TA2 xenografts from MA-891 inoculation. In addition, STAT3 expression was...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 29 April 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Alessandro Del Gobbo, Giovanna Scarfone, Fedro Alessandro Peccatori, Antonella Villa, Wally Ossola, Giulia Ercoli, Silvano Bosari, Stefano Ferrero, Francesca Laura Boggio, Elena Grossi, Fulvia Milena Cribiù
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
CONCLUSIONS: The observed rate of pregnancy is comparable to the literature. There is a lack in fertility counseling of breast cancer patients, and the rate of use of fertility preservation techniques is very low despite prior knowledge about their availability. PMID: 32388348 [PubMed - as supplied by publisher]
Source: Breast - Category: Cancer & Oncology Authors: Tags: Breast Source Type: research
This study investigated the charact...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Publication date: Available online 19 March 2020Source: Reproductive ToxicologyAuthor(s): Dean P. Jones, Barbara A. Cohn
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
Kirsty Guy, 30, from Ellesmere Port, Cheshire, assumed a lump in her right breast was a symptom of her pregnancy and claims she was reassured by her GP.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Abstract Breast cancer (BC) is the most common malignancy in women with a significant increasing incidence during the reproductive life. However, based on the newest anti-cancer molecular targeting drugs, successful treatments lead to the disease healing particularly in young patients, thus refreshing their motherhood programs. However, as effect of the BC treatment, a premature depletion of the ovarian follicle reserve occurs in more than one-third of patients resulting in permanent infertility. To prevent the cancer treatment-related infertility (CTRI), several options are today utilized. Besides the ovary suppr...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Cancer Res Clin Oncol Source Type: research
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