GSE146911 Antitumor Activity of Z-endoxifen in Aromatase Inhibitor-Sensitive and Resistant Estrogen Receptor-Positive Breast Cancer

Contributors : Swaathi Jayaraman ; Xiaonan Hou ; Mary J Kuffel ; Vera J Suman ; Tanya L Hoskin ; Kathryn E Reinicke ; David G Monroe ; Krishna R Kalari ; Xiaojia Tang ; Megan A Zeldenrust ; Jingfei Cheng ; Elizabeth S Bruinsma ; Sarah A Buhrow ; Renee M McGovern ; Stephanie L Safgren ; Chad A Walden ; Jodi M Carter ; Joel M Reid ; James N Ingle ; Matthew M Ames ; John R Hawse ; Matthew P GoetzSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe overarching goal of this study was to explore the antitumor activity of Z-endoxifen, a tamoxifen metabolite, with first-line endocrine therapies tamoxifen and letrozole in the letrozole-sensitive MCF7 aromatase expressing model (MCF7AC1), and with second-line endocrine therapies including tamoxifen, fulvestrant, exemestane, and exemestane plus everolimus, in letrozole-resistant MCF7 model (MCF7LR) in vivo.We used microarray to identify genes that are commonly and differently reguated by Z-endoxifen and tamoxifen treatments in the letrozole-resistant MCF7LR tumors.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research