Volumetric arc therapy treatment plan dosimetry correction method to account patient weight loss during a course of radiation therapy

Conclusion: Image-guided radiation therapy process detects the weight loss, which affects the treatment plan's dose distribution and should be corrected. Applying the correction method described here keeps the patient dosimetry within 1% of the original plan, which is clinically acceptable. The process of plan dosimetry correction to address weight loss can be completed within 30 min without repeating imaging and planning process.
Source: Journal of Medical Physics - Category: Physics Authors: Source Type: research

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1360Objectives: Radiation therapy (RT) is an important component of care in the treatment of many head and neck cancers (HNC). Photon RT vasculitis is a potential risk of incidental dose delivery to the nearby vascular structures. However, optimal methods for early diagnosis are not clearly established. The aim of this study was to evaluate the utility of FDG-PET/CT in detecting radiation-induced vasculitis of the left common carotid (LCC) and the arch of the aorta (AoA) in patients treated for HNC. Methods: FDG-PET/CT scans obtained before RT (Pre-RT) and 3 months after RT (Post-RT) were retrospectively reviewed in 31 HNC...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Other Solid Tumors (Poster Session) Source Type: research
Conclusions: The purpose of this educational item is to establish the power of FDG-PET/CT as a reliable method to identify and track metabolic changes in glucose uptake in HN cancer patients. This technique can be used to monitor systemic inflammatory changes as a result of RT and related to chemotherapy, which can be of use in the management of off-target complications, such as in the parotid gland or in nearby vascular structures. Future prospective studies should be conducted using FDG-PET/CT to compare patient outcomes with proton and photon RT, as well as to identify areas of the body that may be prone to inflammatory side effects.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Oncology Poster Session (Educational Exhbits) Source Type: research
Abstract Early animal studies suggest that parotid gland (PG) toxicity prediction could be improved by an accurate estimation of the radiation dose to sub-regions of the PG. Translation to clinical investigation requires voxel-level dose accumulation in this organ that responds volumetrically throughout treatment. To date, deformable image registration (DIR) has been evaluated for the PG using only surface alignment. We sought to develop and evaluate an advanced DIR technique capable of modeling these complex PG volume changes over the course of radiation therapy. Planning and mid-treatment magnetic resonance imag...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
The epidemiology of oropharyngeal cancer is evolving. Previously, this disease was frequently observed in patients with substantial tobacco and alcohol use[1]. More recently, human papillomavirus (HPV) related oropharyngeal cancer is increasing in incidence, particularly in young and non-smoking patients.[2,3]. The prevalence of HPV related oropharynx cancer has increased from 40% of all cases in Radiation Therapy Oncology Group (RTOG) 9003 to 68% on RTOG 0129 and 73% on RTOG 0522[4,5].p16 immunohistochemistry is a reliable surrogate for determining HPV status[6].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
CONCLUSION: Induction chemotherapy with Cisplatin and Docetaxel is a promising regimen with good response and favorable toxicity profile and can be considered as a potentially effective outpatient regimen for locally advanced squamous cell carcinoma of head and neck. PMID: 32212813 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Conclusions: At the time of writing of this study, there were more than 12,000 medical linear accelerators in clinical use, and XMLC can prove itself useful wherever linac is equipped with MLC but cannot delivery latest techniques, such as volumetric modulated arc therapy.
Source: Journal of Medical Physics - Category: Physics Authors: Source Type: research
CONCLUSIONS: Our work demonstrates the potential to aggregate features from multiple specialties for conditional-outcome predictions using pipelines with varied levels of human interaction. Most importantly, our results provide insights into the importance of data curation and quality, as well as user, data and methodology bias awareness as it pertains to result interpretation in user controlled pipelines. PMID: 32023504 [PubMed - as supplied by publisher]
Source: Health Physics - Category: Physics Authors: Tags: Phys Med Source Type: research
Abstract Positron emission tomography (PET) with 18F-fluordeoxyglucose (FDG) in combination with computed tomography (CT) is well established for the diagnostic work-up of patients with head and neck cancer. Possible applications include the detection of an occult primary tumor metastatic to cervical nodes, locoregional staging, assessment of treatment response to external beam irradiation (also in combination with chemotherapy), and surveillance for recurrence. The success of high-precision irradiation techniques such as intensity-modulated radiation therapy (IMRT) appears to be improved by delineating the tumor ...
Source: Nuklearmedizin - Category: Radiology Authors: Tags: Laryngorhinootologie Source Type: research
AbstractWe evaluated an anthropomorphic head and neck phantom with tissue heterogeneity, produced using a personal 3D printer, with quality assurance (QA), specific to patients undergoing intensity-modulated radiation therapy (IMRT). Using semi-automatic segmentation, 3D models of bone, soft tissue, and an air-filled cavity were created based on computed tomography (CT) images from patients with head and neck cancer treated with IMRT. For the 3D printer settings, polylactide was used for soft tissue with 100% infill. Bone was reproduced by pouring plaster into the cavity created by the 3D printer. The average CT values for...
Source: Radiological Physics and Technology - Category: Physics Source Type: research
The purpose of this study was to investigate the dosimetric impact of weight loss in head and neck (H&N) patients and examine the effectiveness of adaptive planning. Data was collected from 22 H&N cancer patients who experienced weight loss during their course of radiotherapy. The robustness of Intensity Modulated Radiation Therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) treatment plans were compared including the potential need for replanning. The dosimetric impact of weight loss was evaluated by calculating a verification plan for each patient on an assessment CT scan taken during the course of treatment.
Source: Medical Dosimetry - Category: Radiology Authors: Source Type: research
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