Impact of solidification on micromeritic properties and dissolution rate of self-nanoemulsifying delivery system loaded with docosahexaenoic acid.

Impact of solidification on micromeritic properties and dissolution rate of self-nanoemulsifying delivery system loaded with docosahexaenoic acid. Drug Dev Ind Pharm. 2020 Mar 12;:1-33 Authors: Ghosh D, Singh SK, Khursheed R, Pandey NK, Kumar B, Kumar R, Kumari Y, Kaur G, Clarisse A, Awasthi A, Gulati M, Jain SK, Porwal O, Bayrakdar E, Sheet M, Gowthamarajan K, Gupta S, Corrie L, Gunjal P, Gupta RK, Singh TG, Sinha S Abstract Development of self-nanoemulsifying drug delivery systems (SNEDDS) of docosahexaenoic acid (DHA) is reported with the aim to achieve enhanced dissolution rate. The optimized composition of liquid-SNEDDS (L-SNEDDS) formulation was Labrafil® M1944 CS, 47% v/v Tween 80, 27% v/v Transcutol P, and 0.1% v/v DHA. L-SNEDDS were solidified using Syloid XDP 3150 as solid porous carrier. The droplet size, polydispersity index, zeta potential, percentage drug loading and cloud point for L-SNEDDS were found to be 43.51 ± 1.36 nm, 0.186 ± 0.053, -19.20 ± 1.21mV, 93.23 ± 1.71 and 88.60 ± 2.54 °C, respectively. Similarly, for solid-SNEDDS (S-SNEDDS) the above parameters were found to be 101.10 ± 1.87 nm, 0397 ± 0.043, -16.60 ± 2.18 mV, 91.23 ± 1.88 and 89.50 ± 1.18 °C, respectively. The formulatio...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

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