Log in to search using one of your social media accounts:

 

Repurposed drug may be first targeted treatment for serious kidney disease

(Massachusetts General Hospital) A team led by Massachusetts General Hospital researchers is reporting that treatment with abatacept appeared to halt the course of focal segmental glomerulosclerosis in five patients, preventing four from losing transplanted kidneys and achieving disease remission in the fifth.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

Related Links:

This article is protected by copyright. All rights reserved.
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
Authors: Herrmann KH, Meier-Kriesche U, Neubauer AS Abstract Introduction: It is discussed whether real world data can be used in health technology assessment. Following it is of interest whether routinely collected data for quality assurance (QA) in the hospital sector is feasible to address epidemiologic questions in kidney transplantation in the AMNOG process in Germany. Objectives: To investigate the proportion of kidney transplants classified as from so-called standard criteria donors (SCD) and from expanded criteria donors (ECD) in Germany and to study the age distribution. Methods: After granted use by the F...
Source: GMS German Medical Science - Category: General Medicine Tags: Ger Med Sci Source Type: research
Conclusions: Although our pediatric kidney transplant program is a young program it has had successful patient outcomes comparable to international programs. Our study provides evidence that in addition to legal and ethical issues with commercial transplant, it also carries significantly higher morbidity and reduced graft and patient survival. PMID: 29467993 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Abstract Background: Risk analysis of cold ischemia time (CIT) in liver transplantation has largely focused on patient and graft survival. Post‐transplant length of stay is a sensitive marker of morbidity and cost. We hypothesize that CIT is a risk factor for post‐transplant prolonged length of stay (PLOS) and aim to conduct an hour‐by‐hour analysis of CIT and PLOS. Methods: We retrospectively reviewed all adult, first‐time liver transplants between March 2002 and September 2016 in the United Network for Organ Sharing database. 67,426 recipients were categorized by hourly CIT increments. Multivariable logistic re...
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
Conclusionswe observed a shift in histopathology of failed liver grafts, with increasing relevance of chronic idiopathic hepatitis associated with progressive fibrosis and graft failure.This article is protected by copyright. All rights reserved.
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
This article is protected by copyright. All rights reserved.
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Tags: Review Article Source Type: research
This article is protected by copyright. All rights reserved.
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
Authors: Indrová M, Rossowska J, Pajtasz-Piasecka E, Mikyšková R, Richter J, Rosina J, Sedlacek R, Fišerová A Abstract The present study aimed to elucidate the role of cluster of differentiation (CD)8+, CD4+, natural killer (NK), and myeloid (CD11b+) cells in the course of the growth and rejection of experimental major histocompatibility complex (MHC) class I-deficient, HPV16 E6/E7-associated TC-1/A9 tumors in mice. Stable mouse lines (F30) generated by inbreeding of Balb/c and C57BL/6 strains, which were characterized by H-2Db+d-NK1.1neg (B6-neg) and H-2Db-d+NK1.1high (Balb-high)...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
This study demonstrated that human periodontal ligament‐derived stem cells (PDLSCs) reduce retinal ganglion cells (RGC) degeneration induced by optice nerve injury and promote axon regeneration in rats. Human PDLSCs also en‐hance RGC survival and neurite outgrowth in the retinal explant culture model through direct PDLSC‐RGC interaction and neurotrophic factor secretion from human PDLSCs.
Source: Stem Cells - Category: Stem Cells Authors: Tags: Regenerative Medicine Source Type: research
This article is protected by copyright. All rights reserved
Source: Biotechnology and Bioengineering - Category: Biomedical Science Authors: Tags: Article Source Type: research
More News: Abatacept | Health | Hospitals | International Medicine & Public Health | Orencia | Transplants | Urology & Nephrology