Neonatal Organ and Tissue Donation for Research: Options Following Death by Natural Causes
We report on the recovery of neonatal organs and tissues for research. A working group made up of bioethicists, neonatologists, lawyers, o bstetric practioners as well as organ procurement and tissue banking professionals evaluated legal, ethical and medical issues. Neonatal donor family members were also consulted. Our primary goals were (a) to ensure that referrals were made in compliance with all applicable federal and state laws, r egulations and institutional protocols, and (b) to follow acceptable ethical standards. Algorithms and policies designed to assist in the evaluation of potential neonatal donors were developed. Neonatal donation is proving increasingly valuable for research into areas including diabetes, pulmonary, gastrointestinal, genitourinary and neurological development, rheumatoid arthritis, autism, childhood psychiatric and neurologic disorders, treatment of MRSA infection and pediatric emergency resuscitation. The development of policies and procedures will assist medical professionals who wish to offe r the option of donation to family members anticipating the death of a neonate.
CONCLUSIONS: The average patient is middle aged (often male) with a history of subacute back pain, sometimes presenting fever and/or neurological damage on diagnosis. Acute phase reactants are frequently raised. Diabetes mellitus, endocarditis and immunosuppressed patients may have the worst chance of a good outcome, therefore these patients should be more carefully managed (always try to obtain an imaging-guided biopsy, correct antibiotic treatment, and a functional and clinical follow-up). PMID: 32446680 [PubMed - as supplied by publisher]
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TYPE 2 diabetes does not pose a threat if you keep blood sugar levels under control. Diet acts as the ultimate bulwark against high blood sugar levels and a natural green powder has been proven to lower blood sugar.
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This study, for instance, attributes a patient’s waitlist/transplant outcome to the very last dialysis facility the patient was associated with. In epidemiology speak, this means the causal inference authors are trying to draw between for-profit status and good transplant outcomes is subject to time-varying confounding. As an example, if one is seeking an association between testosterone levels and risk of a heart attack, using the last testosterone level available would be a poor way of doing this study because testosterone levels are known to vary over time. The same applies to dialysis facilities. Patie...
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Kehinde S. Olaniyi, Oluwatobi A. Amusa
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Derek Lowe in his Science Magazine blog asks the obvious question. Why the hell are we still conducting trials of hydroxychloroquine for Covid-19 and why are doctors giving it to people. The verdict is in. It doesn't work. On the contrary, it kills people. He discusses this paper inThe Lancet which is a retrospective observational study -- yes, yes, not a randomized controlled trial but quite compelling:[W]hen compared with mortality in the control group [i.e., people hospitalized with Covid-19 who did not receive HCQ] (9 ·3%), hydroxychloroquine (18·0%; hazard ratio 1·335, 95% CI 1·223–1&...
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