Nephroprotective Effects of TVP1022, a non-MAO inhibitor S-Isomer of Rasagiline, in Experimental Model of Diabetic Renal Ischemic Injury.

Nephroprotective Effects of TVP1022, a non-MAO inhibitor S-Isomer of Rasagiline, in Experimental Model of Diabetic Renal Ischemic Injury. Am J Physiol Renal Physiol. 2013 Nov 6; Authors: Abu Saleh N, Awad H, Khamaisi M, Armaly Z, Karram T, Heyman SN, Kaballa A, Ichimura T, Holman J, Abassi ZA Abstract Abstract Ischemic acute kidney injury (iAKI) in diabetes mellitus is associated with a rapid deterioration of kidney function, more than in non-diabetic subjects. TVP1022, non-MAO inhibitor S-isomer of rasagiline, possesses anti-oxidative and anti-apoptotic activities. The current study examines the effects of TVP1022 and Tempol, on iAKI in diabetic rats. Diabetes was induced by Streptozotocin. iAKI was induced by clamping left renal artery for 30 min, in both diabetic and non-diabetic rats. Right intact kidney served as control. 48 h following ischemia, urinary flow (V), sodium excretion (UNaV) and glomerular filtration rate (GFR) in both ischemic and non-ischemic kidneys were determined. The nephroprotective effects of tempol and TVP1022 were examined in these rats. Hematoxylin and eosin staining, 4HNE immunofluorescent and nitrotyrosine immunohistochemistry were performed on renal tissues of the various experimental groups. Compared with normoglycemic rats, iAKI in diabetic animals caused more profound reductions in V, UNaV, and GFR. Tempol and TVP1022 treatment increased GFR by two and four fold in diabetic ischemic kidney, respectively. Besi...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research