Enantioselective remote C-H activation directed by a chiral cation

We report here a strategy to render a common bipyridine ligand anionic and pair its iridium complexes with a chiral cation derived from quinine. We have applied these ion-paired complexes to long-range asymmetric induction in the desymmetrization of the geminal diaryl motif, located on a carbon or phosphorus center, by enantioselective C–H borylation. In principle, numerous common classes of ligand could likewise be amenable to this approach.

Source: ScienceNOW - March 11, 2020 Category: Science Authors: Genov, G. R., Douthwaite, J. L., Lahdenperä, A. S. K., Gibson, D. C., Phipps, R. J. Tags: Chemistry reports Source Type: news