Premenopausal Osteoporosis Poses Special Clinical Challenges

ATLANTA—Osteoporosis in premenopausal women is uncommon compared with its frequency in post-menopausal women, but when it is suspected, it poses some difficult questions for clinicians: How should it be diagnosed in this understudied population? If found, should it be treated—and how? Elizabeth Shane, MD, professor of medicine at Columbia University and attending physician at New... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: 2019 ACR/ARP Annual Meeting Conditions Osteoporosis premenopause Source Type: research

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Conclusion: Among all the three groups, the salivary calcium levels do exhibit the correlation with bone mineral density. In the post-menopausal group, there was significant increase in salivary calcium level compared to other groups. Similarly, the study showed a negative correlation between salivary calcium and serum oestrogen. This substantiates the point that salivary calcium levels can definitely indicate the possibility of the presence or absence of osteoporosis in post-menopausal women.
Source: Indian Journal of Dental Research - Category: Dentistry Authors: Source Type: research
Authors: Paciuc J Abstract As longevity expands, women are spending a third of their existence in menopause and beyond. The vast majority suffer from symptoms that negatively impact their quality of life. Systemic vasomotor symptoms (VMS) are the classic cluster affecting 80% of peri- and post-menopausal women. Once thought to be relatively brief, they sometimes persist more than 10 years. Compelling, yet enigmatic, is the recent finding that women with bothersome and long VMS compared with age-matched peers often have worst underlying preclinical markers of cardiovascular disease (CVD).Local vulvovaginal and ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
ConclusionAmbiguity associated with risk and prevention may provide women with a false sense of security that they are adequately acting to prevent the disease. Underestimation of their risk of osteoporosis and fracture as well as reluctance associated with AOM may be barriers to osteoporotic fracture prevention.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
Hormone replacement therapy (HRT) is the most effective treatment for vasomotor symptoms associated with menopause and may improve quality of life [1]. HRT is also effective for the prevention of postmenopausal osteoporosis [2]. Multiple HRT combinations are available. The individual drugs and their combination are important in determining their safety and efficacy. It is recognised that different progestogens [3], and estrogens have distinct properties. Guidelines recommend individualising and tailoring HRT according to symptoms and the need for prevention, as well as age, personal and family history, and the woman &rsquo...
Source: Maturitas - Category: Primary Care Authors: Source Type: research
Horm Metab Res 2020; 52: 298-304 DOI: 10.1055/a-1151-2342Clinical studies investigating the relationship between fibroblast growth factor 23 (FGF23) and bone mass are controversial, especially in the healthy renal population. Our study is one of the forefronts investigating the relationship between FGF23 and bone mass parameters in the general population, according to age, sex, menopausal, and nutritional status. Cross-sectional study enrolling 123 volunteers between 20–80 years of age without primary osteoporosis under treatment nor secondary osteoporosis, where bone mass (bone mineral density-BMD, bone mineral cont...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Endocrine Care Source Type: research
Abstract The purpose of this review is to summarize the pathophysiology of complex regional pain syndrome (CRPS), the underlying molecular mechanisms, and potential treatment options for its management. CRPS is a multifactorial pain condition. CRPS is characterized by prolonged or excessive pain and changes in skin color and temperature, and/or swelling in the affected area, and is generally caused by stimuli that lead to tissue damage. An inflammatory response involving various cytokines and autoantibodies is generated in response to acute trauma/stress. Chronic phase pathophysiology is more complex, involving th...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
TUESDAY, April 28, 2020 -- Social factors might be significant contributors to coexisting metabolic syndrome (MetS) and osteoporosis (OP) in postmenopausal women, according to a study published online April 20 in Menopause. Hansongyi Lee, Ph.D.,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
CONCLUSIONS: Visceral obesity played a crucial role in the development of osteoporosis in ovariectomized rats through effects that might involve both osteoblasts and osteoclasts. PMID: 32339647 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - Category: Geriatrics Authors: Tags: Exp Gerontol Source Type: research
(The North American Menopause Society (NAMS)) The increased prevalence of metabolic syndrome and osteoporosis in postmenopausal women has prompted multiple research studies to understand why. A new study from South Korea examined the association of socioeconomic status-related factors, unhealthy lifestyles, and diet-related factors with the coexistence of metabolic syndrome and osteoporosis. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionsIn conclusion, underreporting of a substantial proportion of fracture events will influence any model of fracture risk prediction and induce bias when estimating the associations between candidate risk factors and incident fractures.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
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