Amyloid Plaques Containing Nucleic Acids Drive Neuroinflammation in Alzheimer's Disease

Alzheimer's disease is characterized by the presence of protein aggregates in the brain. These are misfolded and altered versions of proteins that can act as seeds for solid deposits to form and spread in the brain. These deposits are surrounded by a halo of toxic biochemistry that harms and eventually kills neurons. Amyloid-β aggregates are present in the early stages of the condition, while tau aggregates cause much greater harm and cell death in the later stages. Alzheimer's disease is also an inflammatory condition, however, in which chronic inflammation and altered behavior of the central nervous system immune cells known as microglia is clearly very influential. The interaction between amyloid-β, tau, and inflammation is somewhat debated. One view is that early amyloid-β aggregation causes microglia to become dysfunction and inflammatory, and this behavior generates an environment of chronic inflammation that results in tau aggregation. Alternatively, amyloid-β accumulation may just be a side-effect of persistent infections that produce chronic inflammation in the brain. Both of these options might be true to varying degrees in different patients. It is quite challenging to pick apart the mechanisms of early Alzheimer's in humans, as it isn't feasible to open up large numbers of living brains to take a look at their biochemistry. Today's research materials add support for the more complex picture of differing contributions and interacti...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs

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We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. METHODS: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. RESULTS: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those workin...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
AbstractAlcohol fermentation is a key process in wine, beer, alcoholic beverage production, bioethanol production by means of carbohydrate sources, and food industry byproducts. There are three key points in these kinds of processes determining their efficiency; enzymatic cellulose lysis into simple sugar molecules, alcohol fermentation rate, and ethanol tolerance of yeast cells. The first process is usually carried out by either the use of pure cellulolytic enzymes, which is a high cost procedure, or by the production of these enzymes from cellulolytic bacteria and filamentous fungi. Lately,Saccharomyces cerevisiae and se...
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
In this study, the plasmid pHBintE, routinely used for gene disruption inBacillus megaterium, was used for the first time to inactivate genes in lactobacilli. Strains with inactivated genes for endogenous lactate dehydrogenases efficiently fermented sugars released by enzymatic hydrolysis of alkali pre-treated wheat straw, an abundant lignocellulose-containing raw material, producing 0.37 –0.42 g of lactate per gram of solid part of alkali-treated wheat straw. Thus, the constructed strains are primed to serve as producers of both optically pure L-lactate and D-lactate in the next-generation biorefineries.Graphic abstract
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
Publication date: Available online 12 July 2020Source: Autoimmunity ReviewsAuthor(s): Dario Roccatello, Roberta Fenoglio, Simone Baldovino, Carla Naretto, Michela Ferro, Antonella Barreca, Daniela Rossi, Savino Sciascia
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Publication date: Available online 11 July 2020Source: Journal of Neuroscience MethodsAuthor(s): Chen Fang, Chunfei Li, Parisa Forouzannezhad, Mercedes Cabrerizo, Rosie E. Curiel, David Loewenstein, Ranjan Duara, Malek Adjouadi, for the Alzheimer's Disease Neuroimaging Initiative
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Conclusion: These results indicate that miR-376a-3p and miR-598-3p were related to cognitive impairment after hearing loss. PMID: 32646202 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Otorhinolaryngology - Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research
TYPE 2 DIABETES is akin to walking a tightrope - one misstep and your blood sugar is out of balance. Which 50p vegetable has been proven to reduce blood sugar and prevent complications?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
We report a case of TBIRS in an Arab patient with mixed connective tissue disease (MCTD). Investigations revealed a clinical condition marked by positive anti-insulin receptor and ribonucleoprotein antibodies. The patient presented with severe hyperglycemia, weight loss, arthralgia, and acanthosis nigricans. He was managed successfully with an intensive pulsed combination regimen of cyclophosphamide and plasmapheresis augmented with high doses of prednisolone, which normalized his blood sugar levels without insulin therapy. MCTD was controlled by hydroxychloroquine. During the course of his treatment, the patient developed...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
We report a new class of natural-product-inspired covalent inhibitors of telomerase that target the catalytic active site. Age-Related Epigenetic Changes that Suppress Mitochondrial Function https://www.fightaging.org/archives/2020/03/age-related-epigenetic-changes-that-suppress-mitochondrial-function/ Today's open access research reports on two specific epigenetic changes observed in old individuals that act to reduce mitochondrial function. This joins an existing list of genes for which expression changes are known to impact mitochondrial function with age. A herd of hundreds of mitochondria are found ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Science - The Huffington Post - Category: Science Source Type: news
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