Use of Post-Operative External Beam Radiation Therapy in Patients with Differentiated Thyroid Cancer
The incidence of thyroid cancer has been on the rise in recent decades with approximately 90% of these being differentiated thyroid carcinomas (DTCs) (including papillary and follicular). The majority of DTCs have a good prognosis and are potentially curable with standard treatment, the cornerstone of which is thyroidectomy. Commonly, patients may also receive adjuvant thyroid stimulating hormone suppression or radioactive iodine-131 (RAI). Due to a lack of randomized clinical trials, the role of adjuvant external beam radiation therapy (EBRT) in DTC is not well-established.
To report control and toxicity outcomes for patients with adenoid cystic carcinoma (ACC) of the non-skull base head and neck treated at a single institution with proton therapy.
Adenoid cystic carcinoma (ACC) is a rare tumor, with variable growth pattern and propensity for distant metastasis. Factors affecting prognosis are under-studied. In this retrospective study, we describe a population of ACC patients (pts) treated at our institution and identify factors associated with survival.
We report our institutional outcome of elective nodal irradiation in this cohort
Papillary thyroid carcinoma (PTC) represents approximately 90% of all the thyroid carcinomas. Curative surgical resection, followed by radioactive iodine treatment according to risk assessment strategy, is the standard of care with a median overall survival of 10 years. Approximately 20% of PTC recur, and about 5% develop distant metastases. BRAF gene, which encodes for a serine/threonine protein kinase, driving the downstream MAP kinase signaling pathway, is one of the commonly mutated genes in PTC patients.
Adenoid cystic carcinoma (ACC) is a locally aggressive salivary gland neoplasm with a propensity for distant recurrence in the lungs. Little is known about the impact of local and systemic therapies for advanced ACC. We explore the long-term natural history of advanced ACC and the clinical utility of molecular alterations.
Lymph node evaluation with sentinel lymph node biopsy is indicated by the NCCN for Merkel cell carcinoma (MCC) of the head and neck. The aim of the study is to evaluate the effect of receipt of lymph node evaluation (LNE) on potential survival impact and pathologic staging of patients with clinically node negative, non-metastatic disease of the head and neck. We hypothesized there to be a mortality benefit with LNE.
Odontogenic cancers comprise a rare subgroup of head and neck cancers including ameloblastic carcinomas and odontogenic carcinomas. Given the limited data to guide treatment decisions, we report the treatment patterns and survival outcomes of patients with odontogenic cancers using the National Cancer Database (NCDB).
Adenoid cystic carcinoma (ACC) is a biphasic tumor arising from the secretory glands with high biological variability. We conducted an integrative analysis of DNA, RNA sequencing and quantitative assessment of total and post-translationally modified proteins in a well-characterized cohort of ACC patients to identify molecular characteristics associated with distinct phenotypes and propose a classification with potential therapeutic implications.
Opinion StatementThe main purpose of the TNM system is to provide an anatomic-based classification to adequately depict cancer prognosis. Accurate cancer staging is important for treatment selection and outcome prediction, research design, and cancer control activities. To maintain clinical relevance, periodical updates to TNM are necessary. The recently published 8th edition TNM classification institutes the following changes to the staging of head and neck (excluding thyroid cancer): new stage classifications [HPV-related oropharyngeal cancer (HPV+ OPC) and soft tissue sarcoma of the head and neck (HN-STS)] and modificat...
CONCLUSIONSSMSGs originate predominately from the head and neck and are more common in older men. Overall, the FNAB diagnosis of SMSG is accurate, but diagnostic challenges can be encountered, especially in SCC types of SMSG. Ancillary studies are needed for the definitive diagnosis of challenging cases. Cancer Cytopathol 2016. © 2016 American Cancer Society.