Genetic and micro-environmental factors influencing response to definitive 30Gy chemo-radiotherapy (chemoRT) in HPV Positive Oropharyngeal Cancer (OPC)

We previously reported outcomes for de-escalated chemoRT in HPV+ OPC by assessing tumor hypoxia with pre and intra-treatment (rx) dynamic 18F-FMISO (fluoromisonidazole) PET. Patients with absence of hypoxia on pre- or intra-rx scan were de-escalated to 30Gy, whereas those who remained hypoxic received 70Gy. Here, we sought to define genetic and/or micro-environmental factors that may influence clinical outcomes to de-escalated therapy.

Source: International Journal of Radiation Oncology * Biology * Physics - March 12, 2020 Category: Radiology Authors: N. Riaz, E. Sherman, X. Pei, H. Schoder, R. Paudyal, N. Katabi, D.J. Ma, C.J. Tsai, S. McBride, L.G. Morris, J.O. Boyle, B. Singh, R.L. Foote, A. Ho, R.J. Wong, J. Humm, A. Dave, D.G. Pfister, J. Reis-Filho, N. Lee Tags: Definitive Management of Head and Neck Squamous Cell Carcinoma Source Type: research