Hyperfractionated Radiotherapy Alone or in Sequential Combination Chemotherapy in Patients with Advanced Nasopharynx Cancer with Contraindications to Concurrent Radio-Chemotherapy - Long Term Results

The standard treatment of patients (pts) with advanced nasopharyngeal cancer (NPC) is conventional fractionated radiotherapy (CFRT) combined with concurrent platinum based chemotherapy (CHT). Induction CHT followed by CFRT or CFRT followed by adjuvant CHT may be effective in selected NPC pts, especially with low differentiated and/or bulky tumors. Our experiences with comorbidity touched HNC pts have recognised concurrent radio-chemotherapy as a too toxic for them and suggested that radiotherapy (RT) alone or RT combined with sequential CHT should be considered.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Definitive Management of Head and Neck Squamous Cell Carcinoma Source Type: research