Examining the Prognostic Impact and Therapeutic Implications of Adjuvant Chemotherapy for Patients with Oral Cavity Squamous Cell Carcinoma and Extranodal Extension

Extranodal extension (ENE) in lymphatic metastases from oral cavity squamous cell carcinoma is an adverse prognostic feature that portends a poor prognosis and adverse outcomes. In a pooled analysis of two randomized controlled trials, a therapeutic benefit with the addition of chemotherapy to adjuvant radiotherapy was demonstrated in patients with ENE. The College of American Pathologists have recently recommended classification of ENE by extent of capsular invasion into minor (2mm) ENE.

Source: International Journal of Radiation Oncology * Biology * Physics - March 12, 2020 Category: Radiology Authors: M. Khan, A. Spreafico, S. Huang, D. Goldstein, A. Hansen, A. Hosni, I. Weinreb, B. Perez-Ordonez, T. Truong, W. Xu, J. de Almeida Tags: Poster Theater Presentations Source Type: research