In Reply to Sari and Yazici

We want to thank our colleagues for this letter and for the great interest they have expressed.1,2 We agree that the diagnosis of solitary plasmacytoma is an important point; therefore, we followed the recommendations for diagnosis and treatment.3-5 We included only solitary plasmacytomas that were confirmed histologically with a biopsy and clinical workup and were absent of any features of multiple myeloma, according to guidelines.4 In particular, bone marrow biopsies were systematically performed to eliminate multiple myeloma (MM) at diagnosis and in the event of suspected myeloma progression or relapse of a new solitary plasmacytoma.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research

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We read the article “Solitary plasmacytoma: Lenalidomide-dexamethasone combined with radiation therapy improves progression-free survival and multiple myeloma-free survival” with great interest.1 It offers a combined treatment for solitary plasmacytoma (SP), which has a significant risk of progression to multiple m yeloma (MM). The diagnosis of SP and elimination of MM should include biopsies from the primary lesion and bone marrow (BM), multiparameter flow cytometry, serum and urine electrophoresis, immunoglobulins (Ig), Free Light Chain assay, Bence-Jones proteins, and skeletal survey with magnetic resonance ...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research
Publication date: Available online 4 December 2019Source: Interdisciplinary NeurosurgeryAuthor(s): Ho Yan Zheng, Senthil Kumar, Mohd Sofan ZenianAbstractPlasma cell neoplasms can present either as multiple myeloma, or in
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Contributors : Shuang Geng ; Jing Wang ; Xiannian Zhang ; Jia-jia Zhang ; Fan Wu ; Yuhong Pang ; Yuping Zhong ; Jianbin Wang ; Wenming Wang ; Xiaoqing Lyu ; Yanyi Huang ; Hongmei JingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo determine the mechanisms of the initial extramedullary translocation of myeloma cells from bone marrow into peripheral blood. We found that the clonal cPCs were more frequently detected by flowcytometry in extramedullary plasmacytoma patients and worsened their prognosis. It is technically much easier to collect single cPCs using FACS than it is to perfor...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Purpose PET/CT with both 11C-choline and 11C-methionine has recently been reported to offer advantages over 18F-FDG for imaging in multiple myeloma (MM). The aim of this study was to directly compare the diagnostic performance of both non-FDG radiotracers in MM patients. Methods Nineteen patients with a history of MM (n = 18) or solitary bone plasmacytoma (n = 1) underwent both 11C-choline and 11C-methionine PET/CT for diagnostic imaging. In this retrospective analysis, scans were compared on a patient and on a lesion basis. In 12 patients, respective tracer uptake in the iliac crest was correlated with the extent of ...
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research
ConclusionThis case report and accompanying literature review highlight the exceedingly rare and easily misclassified entity of primary plasmacytoma of diffuse lymph nodes. Importantly, we demonstrate that this entity may be treated with, and demonstrate excellent response to, systemic therapies often employed in multiple myeloma.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
19Aim: Positron emission tomography/computed tomography (PET/CT) with both 11C-choline and 11C-methionine has recently been reported to offer advantages over 18F-2`-deoxy-2`-fluorodeoxyglucose (FDG) for staging and re-staging in multiple myeloma (MM). The aim of this study was to directly compare the diagnostic performance of both non-FDG radiotracers in MM patients. Methods: Nineteen patients with a history of MM (n=18) or solitary bone plasmacytoma (n=1) underwent both 11C-choline- and 11C-methionine-PET/CT for diagnostic imaging within 10 days (median, 1 day). Scans were compared on a patient and on a lesion basis inclu...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Multiple Myeloma Source Type: research
Rationale: The incidence of extramedullary plasmacytoma (EMP) accounts for 3% to 4% of all cases of generalized plasmacytoma. The most common pathogenic sites are the head and the neck. It is noteworthy that the pathogenic site in this case is extraperitoneal, which is uncommon in clinical practice. In this case report, we aim to discuss the clinical features and diagnosis as well as the treatment methods of EMP. Patient concerns: A 30-year-old female was admitted to our hospital due to a palpable right upper abdominal mass without symptoms of abdominal pain, diarrhea, constipation, fever, or oliguria. Diagnosis and ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
We present the case of a 64-year-old male with known history of MM admitted with acute respiratory failure and a chest wall mass. Chest CT revealed patchy interstitial and alveolar opacities with no pulmonary masses or nodules. Bronchoalveolar lavage (BAL) was performed, with flow cytometry demonstrating monoclonal plasma cells expressing CD38, CD138 and CD56 with lambda light chain restriction. Fine Needle Aspiration of chest wall mass revealed CD138-positive cells as well.Review of the literature revealed only one other documented case of a patient presenting with both interstitial lung parenchymal involvement with MM as...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
ConclusionsThis case illustrates the protean initial manifestations of multiple myeloma and the importance of an accurate diagnosis. Our patient ’s initial presentation with gastrointestinal complaints is rare and the plasmacytoma location is even rarer, providing a challenging diagnostic problem. Prompt recognition of multiple myeloma is critical to institute appropriate therapy and prevention of disease progression.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
My partner Judith had pain in her sinus cavity caused by a tumor called a plasmacytoma. After her biopsy, her surgeon called Friday afternoon with the results. She asked him to wait fifteen minutes until I could be home with her to get the news. He had no flexibility and said he could speak either then or Monday. She chose to speak with him then on the phone still alone. He confirmed that the tumor was cancer of an unknown type. She hurried to the hospital to get more tests to learn what kind of cancer it was. That was a really bad day. Judith and I both work in the health care system. I am a palliative and acute care chap...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Hospital Palliative care Source Type: blogs
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