Mutations of rpoB, katG and inhA genes in multidrug-resistant Mycobacterium tuberculosis isolates from Zambia
Publication date: Available online 10 March 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Eddie S. Solo, Chie Nakajima, Trevor Kaile, Precious Bwalya, Grace Mbulo, Yukari Fukushima, Sylvia Chila, Nanthan Kapata, Yogendra Shah, Yasuhiko Suzuki
NEW BRUNSWICK, NJ, May 27, 2020 — The Janssen Pharmaceutical Companies of Johnson &Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of SIRTURO® (bedaquiline). SIRTURO® is now indicated for use as part of combination therapy in the treatment of adult and pediatric patients (5 years and older and weighing at least 15 kg) with pulmonary multidrug-resistant tuberculosis (MDR‑TB). In the U.S., the medicine should be reserved for use when an effective treatment regimen cannot otherwise be provided. This indication received accelera...
Publication date: Available online 1 April 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Ibrahim Bitar, Medvecky Matej, Amlerova Jana, Papagiannitsis Costas, Hrabak Jaroslav
Publication date: Available online 19 March 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Nilma Hirani, Ameeta Joshi, Siddharth Anand, Abhay Chowdhary, Karthik Ganesan, Meenal Agarwal, Nikhil Phadke
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
ConclusionResistance to INH and RIF was observed at levels similar to those published nationwide, with rates of MDR-TB being somewhat lower. Rates of HIV/TB co-infection have decreased considerably between 2012 and 2016.
ConclusionOur results show strong bactericidal potential of CHP against M.tuberculosis that warrant its immediate mechanistic, pharmacokinetic and pharmacodynamic studies.Graphical abstract
ConclusionWGS ofM. tuberculosis isolates allows the detection of drug resistance to all drugs in a single test and also provides insight into the evolution and drug-resistant TB.
Publication date: Available online 13 November 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Lebogang Kenaope, Hannetjie Ferreira, Faheem Seedat, Kennedy Otwombe, Neil A. Martinson, Ebrahim VariavaAbstractSettingTshepong Hospital multidrug resistant (MDR) unit between April 2011 and February 2014.ObjectiveRifampicin resistant (RR) tuberculosis (TB) on X-pert MTB/Rif is assumed a surrogate for MDR TB. Following a RR result, a second specimen is taken for confirmatory culture and drug susceptibility testing (DST). We compare the initial diagnostic X-pert MTB/RIF result to the confirmatory DST in a high HIV...
ConclusionsResistant MTB isolates in Algeria harbour resistance genotypes similar to other countries, but some rare patterns may result from selection and transmission processes inherent to the country.
Conclusion: Our work demonstrates the utility of machine learning as a flexible approach to drug resistance prediction that is able to accommodate a much larger number of predictors and to summarize their predictive ability, thus assisting clinical decision making and single nucleotide polymorphism detection in an era of increasing WGS data generation.